Vocal fold proteoglycans and their influence on biomechanics
Vocal fold proteoglycans and their influence on biomechanics
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DOI：
10.1097/00005537-199906000-00001
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发表时间：
1999-06-01
期刊：
影响因子：
2.6
通讯作者：
Hammond, TH
中科院分区：
文献类型：
--
作者：
Gray, SD;Titze, IR;Hammond, TH
目的/假设：为了研究声带的间质蛋白及其对该组织生物力学特性的影响，研究设计：结合一些粘度测试的人尸体声带固有层的解剖学研究。方法：用组织化学染色法鉴定蛋白多糖。使用图像分析系统进行定量分析。流变仪用于粘度测试。三维绘制程序是用于计算机图像。结果：蛋白多糖在组织生物力学中起重要作用。透明质酸是影响粘度的关键分子，讨论：固有层的蛋白多糖具有重要的生物学和生物力学作用。透明质酸在确定组织粘度的作用被强调。讨论了粘性对发声阈压和发声所消耗能量的影响。结论：蛋白多糖，特别是透明质酸，在决定组织振荡的生物力学特性中起重要作用。未来的研究可能会使这些蛋白质具有重要的治疗意义。
Objective/Hypothesis: To examine the interstitial proteins of the vocal fold and their influence on the biomechanical properties of that tissue, Study Design: Anatomic study of the lamina propria of human cadaveric vocal folds combined with some viscosity testing. Methods: Identification of proteoglycans is performed with histochemical staining. Quantitative analysis is performed using an image analysis system. A rheometer is used for viscosity testing. Three-dimensional rendering program is used for the computer images. Results: Proteoglycans play an important role in tissue biomechanics. Hyaluronic acid is a key molecule that affects viscosity, Discussion: The proteoglycans of the lamina propria have important biological and biomechanical effects. The role of hyaluronic acid in determining tissue viscosity is emphasized. Viscosity, its effect on phonatory threshold pressure and energy expended due to phonation is discussed. Conclusion: Proteoglycans, particularly hyaluronic acid, play important roles in determining biomechanical properties of tissue oscillation. Future research will likely make these proteins of important therapeutic interest.