Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study.
Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study.
复制标题
原发性闭角型青光眼患者手术前后初级视觉皮层的内在功能连接变化：静息态功能磁共振成像研究
DOI：
10.1371/journal.pone.0170598
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Zeng X
中科院分区：
文献类型：
--
作者：
Li S;Li P;Gong H;Jiang F;Liu D;Cai F;Pei C;Zhou F;Zeng X
目的：应用静息状态功能MRI研究原发性闭角型青光眼（PACG）患者手术前后初级视觉皮层（V1）内在功能连接（iFC）的改变。本研究纳入25例术前PACG （pre-PACG）患者和25例匹配良好的健康对照（hc），并在治疗后至少3个月再次评估9例PACG患者（PACG后）。我们生成了左侧和右侧V1中心种子区域的iFC地图，并进行了分组比较。然后，研究pacg前患者iFC系数变化与临床变量之间的关系。与hc组比较，pacg前患者左侧V1与右侧V2（覆盖楔骨、胼胝体和舌回）间iFC降低，左侧V1与左侧颞顶区、左侧额盖-岛-基底节区、右侧岛-基底节区、右侧顶叶下小叶间iFC升高（P < 0.01，校正）。与pacg前相比，pacg后患者左侧V1与双侧V2之间、左侧V1与左右中央后回之间iFC增高；此外，他们还发现左V1与背侧注意和额顶叶控制网络之间的iFC减少。在pacg前患者中，视觉活动（VA）与左侧V1与左侧颞顶叶或右侧顶叶下小叶之间iFC的增加呈正相关。在pacg前后患者的右侧V1-iFC中观察到类似的改变模式。初步研究结果表明，pacg前患者左侧V1-V2通路视觉信息整合和va相关功能代偿逐渐减少，进一步证明pacg后患者功能恢复。
To investigate the altered intrinsic functional connectivity (iFC) of the primary visual cortex (V1) in primary angle-closure glaucoma (PACG) patients before and after surgery using resting-state functional MRI. Twenty-five preoperative PACG (pre-PACG) patients and 25 well-matched healthy controls (HCs) were included in this study, and 9 PACG patients were assessed again at least 3 months after treatment (post-PACG). We generated the iFC maps of the seed regions in the centers of the left and right V1 and conducted group comparisons. Then, the relationships between the altered iFC coefficients and clinical variables were investigated in the pre-PACG patients. Compared with the HCs, the pre-PACG patients showed decreased iFC between the left V1 and right V2 (covering the cuneus, calcarine and lingual gyrus) and increased iFC between the left V1 and left temporal-parietal region, left frontal opercula-insula-basal ganglia region, right insula-basal ganglia region, and right inferior parietal lobule (P < 0.01, corrected). Compared with the pre-PACG patients, the post-PACG patients showed increased iFC between the left V1 and bilateral V2, and between the left V1 and left or right postcentral gyrus; in addition, they showed decreased iFC between the left V1 and the dorsal-attention and frontoparietal-control networks. In the pre-PACG patients, visual activity (VA) was positively correlated with increased iFC between the left V1 and the left temporal-parietal region or the right inferior parietal lobule. Similar patterns of alterations were observed in the right V1-iFC in both the pre- and post-PACG patients. The primary findings have demonstrated a gradual decrease in visual information integration in the left V1-V2 pathway and VA-related functional compensation in the pre-PACG patients, generating further evidence of functional restoration in post-PACG patients.