Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
复制标题
DOI：
10.1101/gad.308904
复制
发表时间：
2004-11-15
影响因子：
10.5
通讯作者：
Joutel, A
中科院分区：
文献类型：
--
作者：
Domenga, V;Fardoux, P;Joutel, A
功能齐全的动脉的形成是通过多步骤过程进行的。在这里，我们发现Notch3是通过调节血管平滑肌细胞（vSMC）的动脉分化和成熟来在小鼠中生成功能性动脉所必需的。在成年Notch3(-/-)小鼠中，远端动脉表现出结构缺陷，并且动脉生肌反应有缺陷。 Notch3(-/-) 小鼠的 vSMC 出生后成熟阶段存在缺陷。我们进一步表明，Notch3 是 vSMC 的动脉规范所必需的，但内皮细胞的动脉规范则不然。我们的数据显示Notch3是动脉分化和vSMC成熟的第一个细胞自主调节因子。
Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3(-/-) mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3(-/-) mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC.