Dissolution Parameters Reveal Role of Structure and Solvent in Molecular Gelation
Dissolution Parameters Reveal Role of Structure and Solvent in Molecular Gelation
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DOI：
10.1021/la202702r
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发表时间：
2011-11-01
期刊：
影响因子：
3.9
通讯作者：
McNeil, Anne J.
中科院分区：
文献类型：
--
作者：
Muro-Small, Maria L.;Chen, Jing;McNeil, Anne J.
研究了两类化合物在三种不同溶剂体系中的热力学溶解参数（焓和熵）与凝胶化能力之间的关系。总共合成了11种蘸肽和19种吡啶，并分别筛选了它们在水溶剂和有机溶剂中的凝胶化能力。采用van 't霍夫方程从变温溶解度确定溶解参数。这些研究表明，与非凝胶因子相比，大多数凝胶因子具有更高的溶解度和熵，这与凝胶因子在固态下具有更强的分子间相互作用和更有序的概念一致。溶解参数也被发现是溶剂依赖性的，这表明溶剂-溶质相互作用也是重要的凝胶化。总之，这些结果表明，当结构修饰或溶剂变化导致溶出参数增加时，可将非胶凝因子转化为胶凝因子。
The relationship between thermodynamic dissolution parameters (enthalpy and entropy) and gelation ability was examined for two different classes of compounds in three different solvent systems. In total, 11 dip eptides and 19 pyridines were synthesized and screened for gelation in aqueous and organic solvents, respectively. The dissolution parameters were determined from the variable-temperature solubilities using the van't Hoff equation. These studies revealed that the majority of gelators had higher dissolution enthalpies and entropies compared to nongelators, consistent with the notion that gelators have stronger intermolecular interactions and more order in the solid state. The dissolution parameters were also found to be solvent-dependent, suggesting that solvent solute interactions are also important in gelation. Overall, these results indicate that converting nongelators into gelators is attainable when structural modifications or a change in solvent lead to increases in the dissolution parameters.