CHANGES IN CORTICALLY INDUCED INHIBITION IN AMYOTROPHIC LATERAL SCLEROSIS WITH TIME
CHANGES IN CORTICALLY INDUCED INHIBITION IN AMYOTROPHIC LATERAL SCLEROSIS WITH TIME
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DOI：
10.1002/mus.21137
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发表时间：
2009-03-01
期刊：
影响因子：
3.4
通讯作者：
Schmied, Annie
中科院分区：
文献类型：
--
作者：
Attarian, Shahram;Pouget, Jean;Schmied, Annie
皮质内抑制的变化已经通过基于许多神经系统或精神疾病（包括肌萎缩侧索硬化症（ALS））的肌电图记录的成对脉冲经颅磁刺激（TMS）检测到。相比之下，在ALS患者的单运动单位（MU）研究中，抑制反应通常被忽视。本研究的目的是探讨TMS诱导的抑制反应的单个MU的周刺激时间直方图和随时间的变化观察。为此，在10名ALS患者中，在两到四个记录会话中测试了263个MU。在将数据细分为对应于12、20、32、43和168个月的平均疾病持续时间的时期后，我们发现在整个疾病过程中抑制反应比正常情况更频繁地发生，并且在疾病发作后的第一年内比正常情况更强。这一发现反驳了抑制丧失可能是ALS致病过程的一部分的假设。肌肉神经39：310-317，2009
Changes in intracortical inhibition have been detected by means of paired-pulse transcranial magnetic stimulation (TMS) based on electromyographic recordings in many neurological or psychiatric disorders, including amyotrophic lateral sclerosis (ALS). By contrast, inhibitory responses have been generally overlooked in single motor unit (MU) studies in patients with ALS. The aim of this study was to investigate the TMS-induced inhibitory responses of single MUs in peristimulus time histograms and the changes observed with time. For this purpose, 263 MUs were tested in 10 ALS patients in two to four recording sessions. Upon subdividing the data into epochs corresponding to mean disease durations of 12, 20, 32, 43, and 168 months, we found that inhibitory responses occurred more frequently than normal throughout the course of the disease and were stronger than normal during the first year after disease onset. This finding argues against the hypothesis that loss of inhibition may be part of the pathogenic process in ALS. Muscle Nerve 39: 310-317, 2009