Prognostic value of neutrophil lymphocyte ratio in acute ischemic stroke patients either received reperfusion therapy or not
Prognostic value of neutrophil lymphocyte ratio in acute ischemic stroke patients either received reperfusion therapy or not
复制标题
中性粒细胞比率对接受再灌注治疗或未接受再灌注治疗的急性缺血性脑卒中患者的预后价值
DOI：
10.21608/ejhm.2021.175179
复制
发表时间：
2021
影响因子：
4.4
通讯作者：
Amira Mohiey El
中科院分区：
文献类型：
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作者：
Mahmoud Sayed Ahmed Shahin;M. Melake;S. Ibrahim;Amira Mohiey El
背景：很少有研究探讨中性粒细胞-淋巴细胞比值（NLR）与急性缺血性脑卒中（AIS）患者和接受静脉溶栓治疗后的短期预后之间的具体关系。目的：探讨中性粒细胞/淋巴细胞比值与急诊科脑卒中严重程度以及患者是否接受再灌注治疗的短期预后之间是否存在关系，以将其作为急性缺血性脑卒中患者的快速预后标志物。患者和方法：对梅努菲亚大学医院的 56 名急性缺血性卒中患者进行了一项前瞻性比较介入研究。他们是根据某些纳入和排除标准进行选择的。 NLR 通过患者的血液样本进行评估。通过格拉斯哥昏迷评分（GCS）、美国国立卫生研究院卒中量表（NIHSS）评分和改良分级量表（mRS）评估初始卒中严重程度，然后在入院24小时后和一个月后重新评估。结果：预后不良的缺血性脑卒中患者的NLR显着高于预后良好的患者。 NLR 预测不良结果的最佳截断值为 4.15，敏感性为 100%，特异性为 88.5%。结论：无论是否接受再灌注治疗，入院时 NLR 升高是 AIS 患者不良预后的简单而有力的预测指标。
Background: Very few studies have investigated the specific relationship between neutrophil-lymphocyte ratio (NLR) and the short-term prognosis of patients with acute ischemic stroke (AIS) and after receiving intravenous thrombolysis. Objectives: To discuss if there is a relationship between neutrophil-lymphocyte ratio and stroke severity in the emergency department and short-term prognosis whether the patient is treated by reperfusion therapy or not to use it as a rapid prognostic marker in acute ischemic stroke patients. Patients and Method: A prospective comparative interventional study was done on 56 patients with acute ischemic stroke at Menoufia University Hospitals. They were selected according to certain inclusion and exclusion criteria. NLR was assessed from the patients’ blood samples. Initial stroke severity was evaluated by Glasgow Coma Score (GCS), National Institutes of Health Stroke Scale (NIHSS) score and modified ranking scale (mRS), then was re-evaluated later after 24 hours of admission and after one month. Results: NLR among ischemic stroke patients with a bad prognosis was significantly higher than that of the patients who had a good prognosis. The optimal cutoff value of NLR for the prediction of unfavorable outcomes was 4.15 with a sensitivity of 100% and a specificity of 88.5%. Conclusion: Elevated NLR on the hospital admission is an easy and strong predictor of poor outcomes in AIS patients either receiving reperfusion therapy or not.