Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus.
Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus.
复制标题
I 型糖尿病中携带 Ia 抗原的循环 T 细胞增加。
DOI：
10.1056/nejm198204013061305
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Eisenbarth,GS
中科院分区：
文献类型：
--
作者：
Jackson,RA;Morris,MA;Haynes,BF;Eisenbarth,GS
Cahill和McDevitt最近综述了I型糖尿病或需要胰岛素的糖尿病是一种自身免疫性疾病的假设。1该假设得到了抗胰岛抗体的发现、HLA与疾病之间的特征性关联、病程早期发现的胰岛淋巴细胞浸润、和细胞介导的免疫功能异常。1这些发现和免疫疗法在I型糖尿病动物模型中的成功促进了免疫疗法在治疗早期需要胰岛素的糖尿病中的研究。2，3理想地，I型糖尿病的免疫治疗将在大多数人...
THE hypothesis that Type I, or insulin-requiring, diabetes mellitus is an autoimmune disease has recently been reviewed by Cahill and McDevitt.1This hypothesis is supported by the discovery of antiislet antibodies, by characteristic associations between HLA and the disease, by the lymphocytic infiltration of islets found early in the course of the disease, and by abnormalities of cell-mediated immune function.1These findings and the success of immunotherapy in animal models of Type I diabetes have prompted investigation of immunotherapy in the treatment of early insulin-requiring diabetes mellitus.2,3Ideally, immunotherapy of Type I diabetes would be initiated before the majority of . . .