Diurnal patterns and regulation of cortisol secretion in pregnancy.
Diurnal patterns and regulation of cortisol secretion in pregnancy.
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妊娠期皮质醇分泌的昼夜模式和调节。
DOI：
10.1210/jcem-51-3-466
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
E. N. Ehrlich
中科院分区：
文献类型：
--
作者：
W. Nolten;M. Lindheimer;P. Rueckert;S. Oparil;E. N. Ehrlich
Plasma concentrations of cortisol and corticosteroid-binding globulin are elevated substantially in pregnancy; only the free cortisol fraction is biologically active. Previous suggestions that plasma free cortisol increased above nongravid levels in pregnancy were difficult to reconcile with the absence of manifestations of hypercortisolism. Furthermore, any such elevation should be associated with some alteration in the regulation of cortisol secretion. Therefore, the physiology of cortisol secretion was studied by measuring plasma cortisol at 20-min intervals for 24 h. Free cortisol levels were evaluated by determining the plasma free cortisol index and the rate of urinary cortisol excretion. Circadian cortisol patterns in pregnant and nonpregnant subjects were virtually identical, but total plasma cortisol was significantly higher in pregnancy. Calculated plasma biological half-lives and production rates of cortisol were increased significantly in gravidas (t½: pregnant, 104.6 min; nonpregnant, 69.5 mi...
