Natural products as sources for new mechanisms of herbicidal action
Natural products as sources for new mechanisms of herbicidal action
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DOI：
10.1016/s0261-2194(00)00076-4
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发表时间：
2000-09-01
期刊：
影响因子：
2.8
通讯作者：
Dayan, FE
中科院分区：
文献类型：
--
作者：
Duke, SO;Romagni, JG;Dayan, FE
除草剂的新作用机制是非常需要的，以对抗杂草抗性的进化，创造或利用独特的市场利基，并科普新的监管立法。合成除草剂和天然植物毒素的已知分子靶位点的比较表明，几乎没有冗余。相对较少的努力已经花费在确定的网站的行动，从天然来源的植物毒素，这表明，深入研究这些分子将揭示更多的新的作用机制。给出了抑制氨基酸、核酸和其他生物合成途径中未开发步骤的天然产物的实例。AAL毒素，乙内酰脲，和各种植物衍生的萜类化合物进行了讨论。总结了利用天然产物作为新型除草剂先导的策略和潜在的缺陷。出版社：Elsevier Science Ltd
New mechanisms of action for herbicides are highly desirable to fight evolution of resistance in weeds, to create or exploit unique market niches, and to cope with new regulatory legislation. Comparison of the known molecular target sites of synthetic herbicides and natural phytotoxins reveals that there is little redundancy. Comparatively little effort has been expended on determination of the sites of action of phytotoxins from natural sources, suggesting that intensive study of these molecules will reveal many more novel mechanisms of action. Examples of natural products that inhibit unexploited steps in the amino acid, nucleic acid, and other biosynthetic pathways are given. AAL-toxin, hydantocidin, and various plant-derived terpenoids are discussed. Strategies and potential pitfalls of using natural products as leads for new herbicide classes are summarized. Published by Elsevier Science Ltd.