Distribution and heritability of recurrent ear infections
Distribution and heritability of recurrent ear infections
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DOI：
10.1177/000348949710600802
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发表时间：
1997-08-01
影响因子：
1.4
通讯作者：
Magnus, P
中科院分区：
文献类型：
--
作者：
Kvaerner, KJ;Tambs, K;Magnus, P
从1967年至1974年出生的2750对挪威双胞胎的人群样本中获得了复发性耳部感染的分布。自我报告的复发性耳部感染的终生患病率为8.9%，女性病例占明显优势。平均发病年龄为4.2岁，从2岁到7岁逐渐减少。在同卵对中，同卵双胞胎的四分线相关率在男性（0.73,SE 0.08）和女性（0.74,SE 0.06）中几乎相同，但在异卵对中，男性（0.53,SE 0.12）明显高于女性（0.20,SE 0.12）。异性别双卵的值（0.25,SE 0.05）与异性别双卵的值居中。通过结构方程模型估计了基因和环境对中耳炎易感性变异的相对贡献。耳部感染易感性的变化主要由女性的遗传和显性因素解释，其遗传率估计为74%。剩下的26%的责任变化是由个人环境因素解释的。在男性中，45%的变异是由遗传因素造成的，29%是由共同的家庭环境造成的，剩下的26%是由个体环境影响造成的。
The distribution of recurrent ear infections was obtained from a population-based sample of 2,750 pairs of Norwegian twins born between 1967 and 1974. The lifetime prevalence of self-reported recurrent ear infections was 8.9%, with a significant predominance of female cases. The mean age of onset was 4.2 years, with a gradual decrease in occurrence from 2 to 7 years of age. Among monozygotic pairs, the rate of tetrachoric correlation between co-twins was almost identical in males (0.73, SE 0.08) and females (0.74, SE 0.06), but among the dizygotic pairs the correlation was clearly higher in males (0.53, SE 0.12) than in females (0.20, SE 0.12). The value in the unlike-sexed dizygotic twins (0.25, SE 0.05) was intermediate to that of the like-sexed male and female dizygotic pairs. The relative contribution of genes and environment to variability in the predisposition to develop otitis media was estimated by means of structural equation modeling. Variation in liability to ear infections was mainly explained by additive genetic and dominance factors in females, for whom heritability was estimated at 74%. The remaining 26% of the variation in liability was explained by individual environmental factors. In males, 45% of the variation could be accounted for by genetic factors, 29% by common familial environment, and the remaining 26% by individual environmental effects.