Sing the mind electric - principles of deep brain stimulation
Sing the mind electric - principles of deep brain stimulation
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DOI：
10.1111/j.1460-9568.2010.07419.x
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发表时间：
2010-10-01
影响因子：
3.4
通讯作者：
Aziz, Tipu Z.
中科院分区：
文献类型：
--
作者：
Kringelbach, Morten L.;Green, Alexander L.;Aziz, Tipu Z.
深部脑刺激(DBS)对一系列难治性疾病的显著疗效仍不能与对潜在神经机制的可比理解相匹配。使用一系列神经科学技术的转化研究已经取得了一些进展，在这里，我们回顾了最有希望的新兴原则。总的来说，DBS似乎是通过恢复大脑关键区域网络之间的正常振荡活动来发挥作用的。使用这种因果神经调节工具的进一步研究可能会为基本大脑功能提供重要的见解，并为未来的治疗提供指导目标。特别是，DBS可以在恢复大脑默认网络的平衡方面发挥重要作用，从而修复与情感障碍相关的恶性大脑状态，这些状态会导致严重的残疾问题，如快感丧失、缺乏快感。与此同时，谨慎行事也很重要，不要重蹈精神外科时代的覆辙。
The remarkable efficacy of deep brain stimulation (DBS) for a range of treatment-resistant disorders is still not matched by a comparable understanding of the underlying neural mechanisms. Some progress has been made using translational research with a range of neuroscientific techniques, and here we review the most promising emerging principles. On balance, DBS appears to work by restoring normal oscillatory activity between a network of key brain regions. Further research using this causal neuromodulatory tool may provide vital insights into fundamental brain function, as well as guide targets for future treatments. In particular, DBS could have an important role in restoring the balance of the brain's default network and thus repairing the malignant brain states associated with affective disorders, which give rise to serious disabling problems such as anhedonia, the lack of pleasure. At the same time, it is important to proceed with caution and not repeat the errors from the era of psychosurgery.