Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects
Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects
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DOI：
10.1093/ajcn/85.6.1552
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发表时间：
2007-06-01
影响因子：
7.1
通讯作者：
Almer, Lars-Olof
中科院分区：
文献类型：
--
作者：
Hlebowicz, Joanna;Darwiche, Gassan;Almer, Lars-Olof
背景：之前对 2 型糖尿病患者的研究表明，肉桂可降低空腹血糖、三酰甘油、低密度脂蛋白胆固醇和总胆固醇浓度。目的：我们旨在研究肉桂对健康受试者胃排空率、餐后血糖反应和饱腹感的影响。设计：通过使用标准化实时超声检查来测量胃排空率（GER）。通过交叉试验对十四名健康受试者进行了评估。禁食 8 小时后，检查受试者的空腹血糖浓度是否正常。 GER计算为摄入300克八宝粥（GER1）或300克八宝粥和6克肉桂（GER2）后15-90分钟胃窦横截面积的百分比变化。结果：GER 1的中值为37％，GER2的中值为34.5％。在八宝粥中添加肉桂可显着延迟胃排空并降低餐后血糖反应（两者 P < 0.05）。餐后血糖浓度的降低比 GER 的降低更加明显和显着。肉桂对饱腹感的影响不显着。结论：八宝粥中摄入6 g肉桂可降低餐后血糖并延迟胃排空，且不影响饱腹感。饮食中添加肉桂可降低餐后血糖反应，这一变化至少部分可以通过 GER 延迟来解释。
Background: Previous studies of patients with type 2 diabetes showed that cinnamon lowers fasting serum glucose, triacylglycerol, and LDL- and total cholesterol concentrations.Objective: We aimed to study the effect of cinnamon on the rate of gastric emptying, the postprandial blood glucose response, and satiety in healthy subjects.Design: The gastric emptying rate (GER) was measured by using standardized real-time ultrasonography. Fourteen healthy subjects were assessed by using a crossover trial. The subjects were examined after an 8-h fast if they had normal fasting blood glucose concentrations. GER was calculated as the percentage change in the antral cross-sectional area 15-90 min after ingestion of 300 g rice pudding (GER1) or 300 g rice pudding and 6 g cinnamon (GER2).Results: The median value of GER 1 was 37%, and that of GER2 was 34.5%. The addition of cinnamon to the rice pudding significantly delayed gastric emptying and lowered the postprandial glucose response (P < 0.05 for both). The reduction in the postprandial blood glucose concentration was much more noticeable and pronounced than was the lowering of the GER. The effect of cinnamon on satiety was not significant.Conclusions: The intake of 6 g cinnamon with rice pudding reduces postprandial blood glucose and delays gastric emptying without affecting satiety. Inclusion of cinnamon in the diet lowers the postprandial glucose response, a change that is at least partially explained by a delayed GER.