Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics
Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics
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DOI：
10.1007/s002640050086
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发表时间：
1996-10-01
影响因子：
2.7
通讯作者：
Urist, MR
中科院分区：
文献类型：
--
作者：
Gao, T;Lindoholm, TS;Urist, MR
很少有研究已经进行了调查的特性，天然骨形态发生蛋白（BMP）。我们从102公斤新鲜驼鹿骨中提取了5.85克天然驼鹿骨形态发生蛋白，并进行了色谱研究以确定其结构。我们发现BMP分子具有11 - 700 kDa的分子量。为了研究BMP理想的局部递送系统，我们使用多孔盘作为载体：这些被植入132只小鼠。通过组织学标本、X线片和同位素研究评估新骨形成的体积。最好的结果是通过植入多孔盘（珊瑚和陶瓷）与IV型胶原蛋白和BMP。我们认为，这是最好的传输系统，为未来的实验有关的BMP的作用。
Few studies have been performed to investigate the characteristics of native Pone Morphogenetic Protein (BMP). We derived 5.85 g of native moose BMP from 102 kg of fresh moose bone and performed chromatographic studies to characterise its structure. WE found the BMP molecule to have a molecular weight of 11 - 700 kDa. To investigate the ideal local delivery system for BMP we used porous discs as a carrier: These were implanted into 132 mice. The volume of new bone formed was evaluated by means of histological specimens, radiographs and isotope studies. The best results were obtained by implanting porous discs (coral and ceramic) with type IV collagen and BMP. We suggest that this is the best delivery system for future experiments regarding the acton of BMP.