Unilateral lesion of dorsal hippocampus in adult rats impairs contralateral long-term potentiation in vivo and spatial memory in the early postoperative phase
Unilateral lesion of dorsal hippocampus in adult rats impairs contralateral long-term potentiation in vivo and spatial memory in the early postoperative phase
复制标题
成年大鼠背海马单侧损伤损害术后早期对侧体内长时程增强和空间记忆
DOI：
10.1016/j.bbr.2012.02.042
复制
发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Dong, Zhifang
中科院分区：
文献类型：
--
作者：
Li, Hongjie;Wu, Xiaoyan;Dong, Zhifang
出生时的双侧海马病变或单侧海马病变会导致对侧LTP和长期记忆的损害。然而，成人单侧海马病变对对侧体内LTP和记忆的影响尚不清楚。我们在此研究了成年大鼠单侧海马背侧电损伤对术后不同阶段对侧LTP和空间记忆的影响。我们发现急性单侧海马病变对对侧LTP无影响。然而，对侧LTP在病变后1周受损，术后第4周恢复到对照水平。同样，空间记忆也在术后第1周受损，并在术后第4周恢复。此外，术后第1周大鼠在新的开放环境中表现出更强的空间探索行为。假手术在术后第1周和第4周对侧LTP、空间记忆和探查均无影响。这些结果提示，成年大鼠单侧海马背侧病变可引起短暂性对侧LTP损伤和空间记忆缺陷。(C) 2012 Elsevier B.V.版权所有
It is well documented that bilateral hippocampal lesions or unilateral hippocampal lesion at birth causes impairment of contralateral LTP and long-term memory. However, effects of unilateral hippocampal lesion in adults on contralateral in vivo LTP and memory are not clear. We here examined the influence of unilateral electrolytic dorsal hippocampal lesion in adult rats on contralateral LTP in vivo and spatial memory during different postoperative phases. We found that acute unilateral hippocampal lesion had no effect on contralateral LTP. However, contralateral LTP was impaired at 1 week after lesion, and was restored to the control level at postoperative week 4. Similarly, spatial memory was also impaired at postoperative week 1, and was restored at postoperative week 4. In addition, the rats at postoperative week 1 showed stronger spatial exploratory behavior in a novel open-field environment. The sham operation had no effects on contralateral LTP, spatial memory and exploration at either postoperative week 1 or week 4. These results suggest that unilateral dorsal hippocampal lesion in adult rats causes transient contralateral LTP impairment and spatial memory deficit. (C) 2012 Elsevier B.V. All rights reserved.