Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids:: Application to HgCl2 toxicity
Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids:: Application to HgCl2 toxicity
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DOI：
10.1021/pr050399w
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发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Nicholson, J. K.
中科院分区：
文献类型：
--
作者：
Holmes, E.;Cloarec, O.;Nicholson, J. K.
一种新的多变量统计方法，基于一个内置的正交滤波器（OPLS-DA）加上光谱相关方法统计总相关光谱（STOCSY）的潜在结构分析的投影的新组合，被用来表征在体内代谢途径扰动的模型肾皮质毒素氯化汞，在大鼠中，使用尿液作为指标的代谢稳态破坏。该方法为生物标志物提取和鉴定提供了一种公正、灵敏的方法，并显示出产生潜在的新型途径连接性的潜力。
A new multivariate statistical approach, based on the novel combination of projection on latent structure analysis with an inbuilt orthogonal filter (OPLS-DA) coupled with a spectroscopic correlation method statistical total correlation spectroscopy (STOCSY), was used to characterize the in vivo metabolic pathway perturbations of a model renal cortical toxin HgCl2, in the rat, using urine as an indicator of metabolic homeostasis disruption. This method provided an unbiased, sensitive approach to biomarker extraction and identification, and showed potential for generating potential novel pathway connectivities.