MRI of muscular fat
MRI of muscular fat
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DOI：
10.1002/mrm.10107
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发表时间：
2002-04-01
影响因子：
3.3
通讯作者：
Jacob, S
中科院分区：
文献类型：
--
作者：
Schick, F;Machann, J;Jacob, S
建立了一种对脂肪酸亚甲基和甲基质子化学位移范围内的信号成分具有高选择性和灵敏度的磁共振成像技术，用于体内肌肉脂肪的无创性评估。损坏的梯度回波序列由6个等距脉冲和2degrees-(-9degrees)-17degrees-(-17degrees)-9degrees-(-2degrees)和多回波序列(TE=16、36、56、76、96和116ms)空间光谱激发，允许以每像素78赫兹的接收器带宽记录一系列图像。比较了脂肪含量在0.1%~100%的体模和纯净水中的SIS。采用单体素刺激回声采集模式(STEAM)技术，对30名健康志愿者的小腿进行脂肪选择性成像，并对胫前肌和比目鱼肌进行平行定位质子波谱分析(TR=2 S，TE=10ms，TM=15ms)。结果表明，考虑到肌肉组织中总脂肪含量的百分比，比目鱼肌的脂肪成像与光谱方法具有很高的相关性(r=0.91)。胫前肌的相关系数明显较低(r=0.55)，这是由于图像中邻近皮下脂肪的信号污染、脂肪分布不均匀以及该肌肉中的脂肪含量普遍较低所致。新成像技术的应用显示，小腿肌肉组织中脂质的空间分布存在显著的个体内和个体间差异。肌脂与皮下脂肪层厚度无显著相关性。此外，体重指数似乎不能决定肌肉脂肪的含量，除非是非常肥胖的病例。(C)2002年Wiley-Liss，Inc.
An MRI technique with high selectivity and sensitivity to the signal components in the chemical shift range of methylene and methyl protons of fatty acids has been developed for noninvasive assessment of muscular fat in vivo. A spoiled gradient-echo sequence with spatial-spectral excitation by six equidistant pulses with 2degrees-(-9degrees)-17degrees-(-17degrees)-9degrees-(-2degrees) and a multi-echo train (TE = 16, 36, 56, 76, 96, and 116 ms) allowed a series of images to be recorded with a receiver bandwidth of 78 Hz per pixel. SIs from phantoms with lipid contents between 0.1% and 100% were compared to those from pure water. Thirty healthy volunteers underwent fat-selective imaging of their lower leg, and parallel localized proton spectroscopy of the tibialis anterior and the soleus muscle by a single-voxel stimulated echo acquisition mode (STEAM) technique (TR = 2 s, TE = 10 ms, TM = 15 ms). Results show a high correlation (r = 0.91) between fat imaging and the spectroscopic approach in the soleus muscle, considering the percentage total fat content of musculature. The correlation coefficient was clearly lower (r = 0.55) in the tibialis anterior muscle due to signal contaminations from adjacent subcutaneous fat in the images, inhomogeneous fat distribution, and generally lower lipid content in this muscle. Applications of the new imaging technique showed marked intra- and interindividual variability in the spatial distribution of lipids in the musculature of the lower leg. No significant correlation of the muscular fat with the thickness of the subcutaneous fat layer was found. In addition, the body mass index does not appear to determine muscular fat content, except in very obese cases. (C) 2002 Wiley-Liss, Inc.