Fluoride release from dental cements and composites: A mechanistic study
Fluoride release from dental cements and composites: A mechanistic study
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DOI：
10.1016/j.dental.2005.04.028
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发表时间：
2006-04-01
期刊：
影响因子：
5
通讯作者：
Rizkalla, AS
中科院分区：
文献类型：
--
作者：
Chan, WLD;Yang, LF;Rizkalla, AS
目标。本研究的目的是(1)比较实验复合材料与市售GICs、树脂改性GICs和复合树脂的氟化物释放情况；(2)评估氟化物的释放过程。商品材料(n=3)按生产厂家说明书制备。实验用复合材料(n=3)由78wt%的过滤器和22wt%的树脂组成。树脂由19wt%的双GMA、38wt%的UDMA、19wt%的TEGDMA和24wt%的HEMA组成。将圆盘标本放入25毫升的去离子水中，放入坐着的聚乙烯瓶中，在37℃下以1.4赫兹的频率摇动，使用氟离子特定电极在不同的时间间隔测量氟的释放，最长可达284天。实验材料的氟离子释放率在第1天内最高(p=0.05)，但在第7天时显著下降。商品玻璃离子水门汀和树脂改性玻璃离子水门汀的氟离子释放率显著高于实验材料和商品材料(p=0.05)。在所研究的材料中，氟的累积释放可以用一个由快速溶解过程中的初始氟释放和随后的长期扩散释放组成的两项方程来充分描述。通过引入HEMA提高了聚合物基质的亲水性，在发生溶解的短期内改善了氟化物的释放。这种释放行为可能是有益的，如果它导致了氟化物储存库，此后可以通过延长较慢的释放来维持该储存库。(C)2005年牙科材料学会。爱思唯尔有限公司出版。保留所有权利。
Objectives. The purpose of this study was (1) to compare the fluoride release profile of an experimental composite to commercial GICs, resin-modified GICs, and composite resins; (2) to assess the fluoride release process.Methods. Commercial materials (n = 3) were prepared according to manufacturers' directions. The experimental composite (n = 3) consisted of 78 wt% filter and 22 wt% resin. The resin consisted of 19 wt% BisGMA, 38 wt% UDMA, 19 wt% TEGDMA, and 24 wt% HEMA. Disc specimens were placed into 25 ml of deionized water in seated polyethylene vials and shaked at 1.4 Hz at 37 degrees C. Fluoride release was measured using a fluoride-ion specific electrode at different time intervals up to 284 days.Results. The fluoride release rate of the experimental composite demonstrated the highest rate of release within the first day (p=0.05), but decreased significantly by day 7. Release rates of the commercial glass-ionomer cements and resin-modified glass-ionomer cements thereafter were significantly higher than the experimental and commercial composites at p=0.05. Among the materials studied, cumulative fluoride release is adequately described by a two-term equation consisting of an initial fluoride release via a rapid dissolution process followed by a long-term diffusive release.Significance. An increase in the hydrophilicity of the polymer matrix through the introduction of HEMA improved the fluoride release over the short term during which dissolution occurs. Such a release behavior could be beneficial if it results in a fluoride reservoir that could be maintained by a prolonged slower release thereafter. (c) 2005 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.