A hybrid SVM-GLM approach for fMRI data analysis.
A hybrid SVM-GLM approach for fMRI data analysis.
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DOI:
10.1016/j.neuroimage.2009.03.016
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发表时间:
2009-07-01
期刊:
影响因子:
5.7
通讯作者:
Wang Z
中科院分区:
文献类型:
--
作者:
Wang Z
The hypothesis-driven fMRI data analysis methods, represented by the conventional general linear model (GLM), have a strictly defined statistical framework for assessing regionally specific activations but require prior brain response modeling which is hard to be accurate. On the contrary, exploratory methods, like the support vector machine, are independent of prior hemodynamic response function (HRF), but generally lack a statistical inference framework. To take the advantages of both kinds of methods, this paper presents a composite approach through combining conventional GLM with SVM. This hybrid SVM-GLM concept is to use the power of SVM to obtain a data-derived reference function and enter it into the conventional GLM for statistical inference. A strategy is also presented to extract the temporal profile from the SVM classifier to be used as the data-derived regressor in SVM-GLM. In simulations with synthetic fMRI data, SVM-GLM demonstrated a better sensitivity and specificity performance for detecting the synthetic activations, as compared to the conventional GLM. With real fMRI data, SVM-GLM showed better sensitivity than regular GLM for detecting the sensorimotor activations.
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