Morphologic analyses of mandible and upper airway soft tissue by MRI of patients with obstructive sleep apnea hypopnea syndrome
Morphologic analyses of mandible and upper airway soft tissue by MRI of patients with obstructive sleep apnea hypopnea syndrome
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DOI：
10.1093/sleep/29.7.909
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发表时间：
2006-07-01
期刊：
影响因子：
5.6
通讯作者：
Sugawara, Junji
中科院分区：
文献类型：
--
作者：
Okubo, Mau;Suzuki, Masaaki;Sugawara, Junji
研究目的：探讨日本男性阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者下颌骨形态特征和上呼吸道软组织体积在判断上呼吸道解剖危险因素中的作用。方法：应用三维磁共振成像软件对31例OSAHS患者和20例正常对照的下颌骨形态参数和上呼吸道软组织体积参数进行分析。结果：两组患者下颌骨内宽(左右下颌关节间距离[IRG和ILG])和下颌骨厚度差异无统计学意义。然而，OSAHS患者下颌骨的发散角度(SM-IRG线与SM-ILG线之间的夹角)、下颌内长度(SM-LG线与SM-LG线的垂直距离)和下颌基面面积均明显小于正常对照组，而肥胖组和非肥胖组之间下颌骨的上述形态参数差异无统计学意义。结论：日本男性OSAHS患者下颌骨底部有一定的解剖学特征，但肥胖似乎是一个不太重要的危险因素。研究人员和临床医生必须意识到，种族可能会改变肥胖和异常颅面解剖作为OSAHS发病危险因素的影响。
Study Objectives: To evaluate the morphological features of the mandible and the volume of the upper airway soft tissues in determining the anatomical risk factors for the upper airway in Japanese male patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods: Five morphological parameters of the mandible at the mandibular base plane and three volumetric parameters of the upper airway soft tissue were analyzed using three-dimensional (3D) magnetic resonance imaging software in 31 OSAHS and 20 controls.Results: There were no significant differences between the two groups in mandibular internal width (the distance between the internal right and left gonia [IRG and ILG]) and mandibular bony thickness. However, the patients with OSAHS had a significantly wider mandibular divergence (the angle between the spina mentalis (SM)-IRG line and SM-ILG line), a smaller mandibular internal length (the perpendicular distance from SM to the RG-LG line), and a smaller area than the normal subjects at the mandibular base plane, There were no significant differences in these morphological parameters for the mandible between obese and nonobese OSAHS patients. The volumes of the tongue, soft palate, and lateral pharyngeal walls were not significantly different between the OSAHS and the control groups.Conclusions: Japanese male OSAHS patients had specific anatomical features in the bottom part of the mandible; however, obesity seemed to be a less significant risk factor. Investigators and clinicians must realize that ethnicity may modify the effects of obesity and abnormal craniofacial anatomy as risk factors for the pathogenesis of OSAHS.