Theoretical considerations on the topological organization of receptor mosaics.
Theoretical considerations on the topological organization of receptor mosaics.
复制标题
DOI：
10.2174/138920309789630606
复制
发表时间：
2009-12
影响因子：
2.8
通讯作者：
Diego G
中科院分区：
文献类型：
--
作者：
Francesco AL;Kjell F;Amina W;Susanna G;Diego G
受体镶嵌（RM）的概念进行了讨论，因此，整合功能的组装G-蛋白偶联受体物理相互作用的质膜的平面。主要关注G蛋白偶联受体的异源三聚体，即A2 A-D2-CB 1受体三聚体。对这些受体的氨基酸序列进行了生物信息学分析，以指示可能参与受体-受体相互作用的结构域。还对由mGLU R5、D2和A2 A形成的RM进行了这样的生物信息学分析。拓扑学的重要性，即，强调了RM整合功能的膜平面中三种相互作用受体的相互定位。然而，也有人指出，这一基本方面仍然等待技术能够适当的调查。最后，它是如何RM拓扑结构可以给暗示的枢纽受体的概念的结构定义。因此，就像在任何网络中一样，作为枢纽的受体是由受体形成的分子网络中具有最多输入的受体。
The concept of Receptor Mosaic (RM) is discussed; hence the integrative functions of the assemblage of G-protein coupled receptors physically interacting in the plane of the plasma membrane. The main focus is on a heterotrimer of G-protein coupled receptors, namely the A2A-D2-CB1 receptor trimer. A bioinformatics analysis was carried out on the amino acid sequence of these receptors to indicate domains possibly involved in the receptor-receptor interactions. Such a bioinformatic analysis was also carried out on the RM formed by mGLU R5, D2 and A2A. The importance of topology, i.e., of the reciprocal localisation of the three interacting receptors in the plan of the membrane for the RM integrative functions is underlined. However, it is also pointed out that this fundamental aspect still waits techniques capable of an appropriate investigation. Finally, it is discussed how RM topology can give hints for a structural definition of the concept of hub receptor. Thus, just as in any network, the receptor operating as a hub is the one that in the molecular network formed by the receptors has the highest number of inputs.