Molecular and cellular mechanisms of leukocyte chemotaxis.
Molecular and cellular mechanisms of leukocyte chemotaxis.
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DOI：
10.1126/science.6266014
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发表时间：
1981-08
期刊：
影响因子：
56.9
通讯作者：
R. Snyderman;E. Goetzl
中科院分区：
文献类型：
--
作者：
R. Snyderman;E. Goetzl
现代科学方法在白细胞功能研究中的应用已经开始揭示这些细胞趋化反应的分子和细胞结构基础。白细胞趋化性是由趋化因子与不同的质膜受体结合而启动的;这一发现改变了跨膜电位并激活了离子通量。随后的一系列代谢过程导致细胞骨架元素的重排，这表现为细胞向趋化梯度源的定向和迁移。
The application of modern scientific methods to the study of leukocyte function has begun to reveal the molecular and cytostructural bases of the chemotactic responses of these cells. Leukocyte chemotaxis is initiated by the binding of chemoattractants to distinct plasma membrane receptors; this finding alters transmembrane potential and activates ionic fluxes. The subsequent sequence of metabolic processes leads to a rearrangement of cytoskeletal elements that is manifested by orientation and migration of the cells toward the source of the chemotactic gradient.