Support for involvement of the AHI1 locus in schizophrenia
Support for involvement of the AHI1 locus in schizophrenia
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DOI：
10.1038/sj.ejhg.5201848
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发表时间：
2007-09-01
影响因子：
5.2
通讯作者：
Stefansson, Hreinn
中科院分区：
文献类型：
--
作者：
Ingason, Andres;Sigmundsson, Thordur;Stefansson, Hreinn
最近，在Abelson辅助整合位点1（AHI 1）区域的标记被证明与以色列-阿拉伯人的家庭样本中的精神分裂症有关。在这里，我们报告了一项研究，评估冰岛样本中AHI 1区域与精神分裂症的相关性。在608名被诊断为广义精神分裂症的患者和1504名对照者中，对先前报告中显示具有风险的七种标志物进行了分型。在冰岛样本中，以色列-阿拉伯家庭中过度传播等位基因的比值比为1.15至1.29。经过Bonferroni校正的七个标志物测试，两个标志物与精神分裂症显着相关。因此，我们的研究结果与以前的报道基本一致，在AHI 1基因上游区域观察到最强的关联信号。
Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.