Prospective study of moderate alcohol consumption and mortality in US male physicians
Prospective study of moderate alcohol consumption and mortality in US male physicians
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DOI：
10.1001/archinte.157.1.79
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发表时间：
1997-01-13
影响因子：
--
通讯作者：
Stampfer, MJ
中科院分区：
文献类型：
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作者：
Camargo, CA;Hennekens, CH;Stampfer, MJ
背景：虽然适度饮酒可降低心肌梗死的风险，但其对健康男性全因死亡率的影响尚不清楚。方法：我们在《内科医生健康研究》中对22071名男性进行了前瞻性队列研究。参与者年龄在40至84岁之间，无心肌梗死、中风、短暂性脑缺血发作或癌症病史。结果：在10.7年的随访中，有1206人死亡（心血管疾病394人，癌症488人，其他疾病324人）。与每周饮酒少于1杯的参与者相比，每周饮酒2至4杯的男性全因死亡率的相对风险（95%置信区间）为0.72 (0.59-0.87)；每周喝5到6杯，0.79 (0.64-0.99)；每天1杯，0.98 (0.84-1.15)；而最高饮酒量组（每天大于或等于2杯）为1.51（1.17-1.95）。这种关联与不饮酒者或偶尔饮酒者作为参照组相似，并且不受任何因素检查的物质混淆或影响改变的影响。总体上，饮酒量最高的人群与心血管疾病死亡率呈j型关系，与癌症死亡率呈上升关系，与其他死因呈u型关系。结论：全因死亡率的风险因饮酒水平而异。在这个明显健康的队列中，每周饮酒2到6杯的男性死亡率最高，而每天饮酒2杯或更多的男性死亡率最高。少量和大量饮酒之间的差异可能意味着预防和导致过度死亡之间的差异。
Background: Although moderate alcohol consumption decreases the risk of myocardial infarction, its impact on all-cause mortality among apparently healthy men is unclear.Methods: We performed a prospective cohort study in 22 071 men in the Physicians' Health Study. Participants were aged 40 to 84 years and had no history of myocardial infarction, stroke, transient ischemic attack, or cancer.Results: There were 1206 deaths (394 cardiovascular, 488 cancer, and 324 other) during 10.7 years of followup. Compared with participants who consumed less than 1 drink per week, the relative risk (95% confidence interval) of all-cause mortality for men who consumed 2 to 4 drinks per week was 0.72 (0.59-0.87); 5 to 6 drinks per week, 0.79 (0.64-0.99); 1 drink per day, 0.98 (0.84-1.15); and the highest drinking group (greater than or equal to 2 drinks per day), 1.51 (1.17-1.95). This association was similar with either nondrinkers or occasional drinkers used as the reference group and was not subject to material confounding or effect modification by any factor examined. The overall relationship was the result of a J-shaped association with cardiovascular mortality, an increase in cancer deaths for the highest drinking group, and a U-shaped association with other causes of mortality.Conclusions: Risk of all-cause mortality varies by level of alcohol consumption. In this apparently healthy cohort, men who consumed 2 to 6 drinks per week had the most favorable mortality profile and men who had 2 or more drinks per day the most unfavorable mortality profile. The difference between consumption of small and large amounts of alcohol may mean the difference between preventing and causing excess mortality.