Correlative analysis of ethanol-related phenotypes in rat inbred strains.
Correlative analysis of ethanol-related phenotypes in rat inbred strains.
复制标题
大鼠近交系乙醇相关表型的相关分析。
DOI：
10.1111/j.1530-0277.1984.tb05707.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Deitrich,RA
中科院分区：
文献类型：
--
作者：
Spuhler,K;Deitrich,RA
作为对近交系大鼠酒精相关性状的总结，分析了8个品系对乙醇的反应。通过偏相关和因子分析，计算各应变均值之间的相关性，进一步确定各应变相关之间的相关性。关于菌株乙醇反应的数据来源包括Deitrich、Li、Erickson、Pohorecky和Tabakoff博士的实验室的测量结果，他们参与了这项关于大鼠异种种群(N/NIH)发展的联合研究。尽管从不同实验室收集的数据来估计品系相关性存在问题，但与乙醇相关的性状之间的一些信息性关联是由近交系菌株分布表明对乙醇的行为和生理反应的明显遗传差异。这些品系对乙醇的反应明显不同，美国国立卫生研究院的种群平均值在近交系分布的范围内居中。对于联合考虑的与酒精相关的特征，提出了初始行为敏感性、酒精摄入量和新陈代谢之间的关联，以及耐受性、初始敏感性的发展和几种生理指标之间的关联。因此，异种大鼠群体，一个系统的异种繁殖群体，应该提供一个有用的动物模型，用来研究乙醇摄取和偏爱的生理绿洲，对急性乙醇的反应，以及耐受性的发展。
As a summary presentation of the ethanol‐related traits in the rat inbred strains, the responses to ethanol for various traits of the eight strains were analyzed. The intercorrelations among the means of the strains were computed and the interrelationships among the strain con‐elations were determined further by partial correlation and factor analysis. Sources of data on strain ethanol response included measures from laboratories of Drs. Deitrich, Li, Erickson, Pohorecky, and Tabakoff, who have participated in this joint study on the development of the rat heterogeneous stock (N/Nih). Although there are problems with estimating strain correlations from data collected in different laboratories, some informative associations among the ethanol‐related traits were apparent Genetic variation for behavioral and physiological responses to ethanol was indicated by the inbred strain distribution. The strains cleariy differed in response to ethanol, with the mean of the National Institutes of Health stock falling intermediate within the range of the inbred strain distribution. For the ethanol‐related traits considered jointly, an association between initial behavioral sensitivity, ethanol intake, and metabolism, as well as an association between development of tolerance, initial sensitivity, and several physiological measures, was suggested. Thus, the rat heterogeneous stock, a systematically outbred population, should provide a useful animal model with which to study the physiological oasis for ethanol intake and preference, response to acute ethanol, and the development of tolerance.