Molecular biology of the renin-angiotensin system.
Molecular biology of the renin-angiotensin system.
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DOI：
10.1152/ajprenal.1988.255.4.f563
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发表时间：
1988-10
期刊：
影响因子：
--
通讯作者：
V. Dzau;D. Burt;R. Pratt
中科院分区：
文献类型：
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作者：
V. Dzau;D. Burt;R. Pratt
本文综述了肾素-血管紧张素系统的分子生物学研究进展。详细分析了肾素基因结构，包括对假定的调控区域的检查。这些调控序列的共同作用将导致体内观察到的复杂的、组织特异性的表达和调控。还描述了可能具有重要生理功能的组织肾素-血管紧张素系统的表达。并对肾素的生物合成和分泌途径进行了综述。这包括对循环泌肾素的命运和多种肾素形式和分泌途径的生理作用的推测。本文中描述的分子方法大大提高了我们对肾素-血管紧张素系统生物学的认识。使用这些方法和其他方法的未来研究应该能进一步深入了解这个复杂的系统。
This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have important physiological functions, is also described. In addition, the pathway of renin biosynthesis and secretion is reviewed. This includes speculation on the fate of circulating prorenin and the physiological role of multiple renin forms and secretory pathways. The molecular approaches described in this paper have greatly advanced our knowledge of the biology of the renin-angiotensin system. Future studies using these and other approaches should provide further insight into this complex system.