Immunomodulatory principles of Dichrocephala bicolor
Immunomodulatory principles of Dichrocephala bicolor
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DOI：
10.1021/np980153o
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发表时间：
1999-03-01
影响因子：
5.1
通讯作者：
Chou, CJ
中科院分区：
文献类型：
--
作者：
Lin, LC;Kuo, YC;Chou, CJ
从双色双头龙乙醇提取物中得到8个化合物-4,5-二咖啡酰奎宁酸(1)；3,4-二咖啡酰奎宁酸(2)；3,5-二咖啡酰奎宁酸(3)；4,5-二咖啡因基醌酸乙酯(4)；甲基3,5-二咖啡因基醌酸酯(5)；5-咖啡酰奎宁酸(6)；咖啡酸(7)；和槲皮素-3- o -芦丁苷(8)-进行分离鉴定。均进行免疫药理活性测定。以人单核细胞（HMNC）为靶细胞。h -3-胸腺嘧啶摄取测定细胞增殖。化合物2和6能增强HMNC的增殖和干扰素γ的产生。增强机制可能涉及细胞因子产生的增加。
From the ethanolic extract of Dichrocephala bicolor eight compounds-4,5-dicaffeoyl quinic acid (1); 3,4-dicaffeoyl quinic acid (2); 3,5-dicaffeoyl quinic acid (3); ethyl 4,5-dicaffeoyl quinate (4); methyl 3,5-dicaffeoyl quinate (5); 5-caffeoyl quinic acid (6); caffeic acid (7); and quercetin-3-O-rutinoside (8)-were isolated and identified. All of them were selected for immunopharmacological activity tesing. Human mononuclear cells (HMNC) were used as target cells. Cell proliferation was determined by H-3-thymidine uptake. Compounds 2 and 6 potently enhanced HMNC proliferation and interferon-gamma production. Enhancement mechanisms may involve the increase of cytokines production.