Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome.
Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome.
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DOI：
10.1177/0271678x17744718
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发表时间：
2019-06
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影响因子：
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通讯作者：
Lawrence CB
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文献类型：
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作者：
Haley MJ;Krishnan S;Burrows D;de Hoog L;Thakrar J;Schiessl I;Allan SM;Lawrence CB
长期食用高脂肪饮食会导致肥胖，并对大脑功能产生负面影响。长期维持高脂肪饮食而肥胖的啮齿动物在实验性中风后的结果更差。仅三天的高脂肪摄入不会导致肥胖，但会对大脑产生快速影响，包括记忆障碍。然而，在没有肥胖的情况下，短期高脂肪喂养或高脂肪消费对中风的影响尚不清楚。因此，我们测试了C57 B/6小鼠急性期高脂肪喂养（3天）对大脑中动脉闭塞（MCAo）后结果的影响。与慢性高脂饮食（7.5个月）相比，急性高脂饮食对体重、脂肪组织、脂质谱或炎症标志物（外周和大脑）没有影响。三天的高脂肪喂养损害了葡萄糖耐量，增加了血糖和胰岛素以及葡萄糖转运蛋白GLUT-1的大脑表达。在喂食急性高脂饮食的小鼠中，缺血性损伤增加（48%），并且与缺血半球中GLUT-1的进一步减少有关。这些数据表明，只有短暂的高脂肪消费对葡萄糖稳态和缺血性卒中后的预后有负面影响。
Chronic consumption of diets high in fat leads to obesity and can negatively affect brain function. Rodents made obese by long-term maintenance on a high-fat diet have worse outcome after experimental stroke. High-fat consumption for only three days does not induce obesity but has rapid effects on the brain including memory impairment. However, the effect of brief periods of high-fat feeding or high-fat consumption in the absence of obesity on stroke is unknown. We therefore tested the effect of an acute period of high-fat feeding (three days) in C57B/6 mice on outcome after middle cerebral artery occlusion (MCAo). In contrast to a chronic high-fat diet (7.5 months), an acute high-fat diet had no effect on body weight, adipose tissue, lipid profile or inflammatory markers (in periphery and the brain). Three days of high-fat feeding impaired glucose tolerance, increased plasma glucose and insulin and brain expression of the glucose transporter GLUT-1. Ischaemic damage was increased (48%) in mice fed an acute high-fat diet, and was associated with a further reduction in GLUT-1 in the ischaemic hemisphere. These data demonstrate that only a brief period of high-fat consumption has a negative effect on glucose homeostasis and worsens outcome after ischaemic stroke.