P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects
P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects
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DOI：
10.1159/000079110
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Swann, AC
中科院分区：
文献类型：
--
作者：
Moeller, FG;Barratt, ES;Swann, AC
先前的研究报告可卡因依赖个体的P300事件相关电位振幅降低。皮质醇依赖也与冲动性增加有关，可能是由于与P300振幅降低相关的认知功能缺陷。在本研究中，可卡因依赖，冲动性和P300振幅之间的关系进行了检查。在健康对照组（n = 14）和符合DSM-IV可卡因依赖标准的受试者（n = 17）中，评估了与听觉古怪事件相关的潜在任务沿着自我报告（Barratt冲动量表第11版）和行为实验室（即时和延迟记忆任务）冲动性测量。与对照组相比，可卡因依赖组的P300振幅降低，自我报告和行为实验室冲动评分升高。有一个冲动性的问卷和行为实验室措施之间的正相关，和冲动性措施和P300振幅之间的负相关。在考虑了儿童期品行障碍症状的数量后，自我报告的冲动性得分与P300振幅之间的相关性仍然存在。这项研究支持的假设，负责可卡因依赖的个人的P300振幅的基本神经生理学与冲动独立的儿童行为障碍症状的历史。版权所有（C）2004 S. Karger AG，巴塞尔。
Previous studies report reduced amplitude of the P300 event-related potential in cocaine-dependent individuals. Cocaine dependence is also associated with increased impulsivity, possibly due to deficits in cognitive function that are associated with reduced P300 amplitude. In the current study, the relationship between cocaine dependence, impulsivity, and P300 amplitude were examined. An auditory oddball event-related potential task along with self-report (Barratt Impulsiveness Scale version 11) and behavioral laboratory (Immediate and Delayed Memory Task) measures of impulsivity were assessed in healthy controls (n = 14) and subjects who met DSM-IV criteria for current cocaine dependence ( n = 17). P300 amplitude was reduced and self-reported and behavioral laboratory impulsivity scores were elevated among the cocaine-dependent group compared to controls. There was a positive correlation between the questionnaire and behavioral laboratory measures of impulsivity, and a negative correlation between impulsivity measures and P300 amplitude. The correlation between self-reported impulsivity scores and P300 amplitude remained after taking into account the number of childhood conduct disorder symptoms. This study supports the hypothesis that the basic neurophysiology responsible for the P300 amplitude in cocaine-dependent individuals is associated with impulsivity independent of a history of childhood conduct disorder symptoms. Copyright (C) 2004 S. Karger AG, Basel.