Role of central prostaglandin E2 in the regulation of gastric acid secretion in the rat.
Role of central prostaglandin E2 in the regulation of gastric acid secretion in the rat.
复制标题
中枢前列腺素 E2 在大鼠胃酸分泌调节中的作用。
DOI：
10.1016/0014-2999(91)90002-8
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发表时间：
1991
影响因子：
5
通讯作者：
Taché,Y
中科院分区：
文献类型：
--
作者：
Saperas,E;Kauffman,G;Taché,Y
本实验观察了前列腺素E_2（PGE_2）对大鼠胃酸分泌的中枢作用。和静脉注射PGE_2以及i.c.注射吲哚美辛对脑和胃中酸分泌和PGE 2生成的影响。I.ci.注射PGE_2（1-10 μg）或稳定的类似物16，16-二甲基PGE_2（0.01-0.1 μg）可剂量依赖性地抑制细菌刺激的胃酸分泌，抑制率分别为0-82%和7-87%。静脉注射PGE_2也能抑制细菌刺激的胃酸分泌，但需要10倍以上的剂量。I.ci.或静脉注射吲哚美辛（50 - 500 μg/只），对胃粘膜和脑皮质的PGE 2生成产生了类似的剂量依赖性抑制作用。I.ci.注射吲哚美辛（500 μg）在10分钟内增加酸分泌，在20-30分钟达到峰值反应;注射后60-120分钟，当前列腺素合成被抑制90%时，基础酸分泌和细菌刺激的酸分泌没有改变。这些结果进一步证实了脑内PGE 2可抑制迷走神经刺激的大鼠胃酸分泌，但不支持内源性脑内PGE 2在胃酸分泌调节中的紧张性抑制作用。此外，这些数据表明i.c. 500 μg不会诱导大脑中前列腺素合成的选择性抑制。
The central action of prostaglandin E2(PGE2) on gastric acid secretion was investigated in rats by comparing the effects of intracisternal (i.ci.) and i.v. administration of PGE2and the influence of i.ci. injection of indomethacin on acid secretion and PGE2generation in the brain and stomach. I.ci. injections of PGE2(1–10 μg) or the stable analog, 16,16-dimethyl PGE2, (0.01–0.1 μg) induced a dose dependent inhibition of baclofen-stimulated gastric acid secretion by 0–82% and by 7–87% respectively. I.v. infusion of PGE2also induced a dose related inhibition of baclofen-stimulated acid secretion, but 10 fold higher doses were required. I.ci. or i.v. injection of indomethacin in doses ranging from 50 to 500 μg/rat, produced a similar dose dependent inhibition of the PGE2generation in both the gastric mucosa and brain cortex measured 1 h post injection. I.ci. injection of indomethacin (500 μg) increased within 10 min acid secretion with a peak response at 20–30 min; 60–120 min post injection, when prostaglandin synthesis was inhibited by 90%, basal and baclofen-stimulated acid output were not altered. These results further establish that PGE2acts in the brain to inhibit vagally stimulated gastric acid secretion in rats, and do not support a tonic inhibitory influence of endogenous brain PGE2in the regulation of gastric acid secretion. In addition, these data showed that indomethacin injected i.ci. at 500 μg does not induce a selective inhibition of prostaglandin synthesis in the brain.