Overview of Drosophila immunity: A historical perspective
Overview of Drosophila immunity: A historical perspective
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DOI：
10.1016/j.dci.2013.08.018
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发表时间：
2014-01-01
影响因子：
2.9
通讯作者：
Imler, Jean-Luc
中科院分区：
文献类型：
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作者：
Imler, Jean-Luc
对模式生物黑腹果蝇基因的功能分析为包括免疫在内的许多细胞和发育或生理过程提供了宝贵的信息。果蝇免疫最被理解的方面是诱导的体液反应，第一次被发现是在1972年。这项开创性的工作在接下来的30年里导致了一系列非凡的发现，从产生的抗菌肽的鉴定和表征，到解密激活抗菌肽编码基因的信号通路，最终发现了感知感染的受体。这些关于昆虫模型的研究恰逢先天免疫领域的复兴，并对生物医学领域产生了意想不到的影响。(C)2013爱思唯尔有限公司。保留所有权利。
The functional analysis of genes from the model organism Drosophila melanogaster has provided invaluable information for many cellular and developmental or physiological processes, including immunity. The best-understood aspect of Drosophila immunity is the inducible humoral response, first recognized in 1972. This pioneering work led to a remarkable series of findings over the next 30 years, ranging from the identification and characterization of the antimicrobial peptides produced, to the deciphering of the signalling pathways activating the genes that encode them and, ultimately, to the discovery of the receptors sensing infection. These studies on an insect model coincided with a revival of the field of innate immunity, and had an unanticipated impact on the biomedical field. (C) 2013 Elsevier Ltd. All rights reserved.