The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats
The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats
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DOI：
10.1002/cbf.1469
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发表时间：
2008-06-01
影响因子：
3.6
通讯作者：
Guenay, Ismail
中科院分区：
文献类型：
--
作者：
Kavak, Servet;Ayaz, Lokman;Guenay, Ismail
我们研究了罗格列酮（RSG）对链脲佐菌素（STZ）诱导的2型糖尿病（DM）大鼠血脂和氧化状态的影响。罗格列酮是过氧化物酶体增殖物激活受体γ（介导胰岛素增敏作用）的高亲和力配体。Wistar白化病雄性大鼠随机分为正常对照组（C）、RSG组（4 mg kg-1）、糖尿病组（D）、RSG组（45 mg kg-1）。测定血脂、血糖、糖化血红蛋白（1c）水平及左心室肌丙二醛（MDA）、3-硝基酪氨酸（3-NT）水平。用RSG治疗D大鼠导致血糖呈时间依赖性降低。我们发现，D + RSG组的血脂和HbA（1c）水平在治疗期结束时达到C大鼠的值。3-NT水平在C + RSG组与C组之间有显著性差异。D组与C、C + RSG、D + RSG组比较，3-NT、MDA含量均明显升高。与C组和C + RSG组相比，D + RSG组的MDA水平降低。本研究结果提示，人参皂甙对D组大鼠左心室组织氧化/亚硝化应激有明显的抑制作用。因此，在糖尿病相关的血管疾病中，RSG治疗可能具有心脏保护作用。版权所有（C）2008约翰威利父子有限公司
We investigated the effect of rosiglitazone (RSG), a high-affinity ligand for the peroxisome proliferator-activated receptor Gamma which mediates insulin-sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)-induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were randomly divided into an untreated control group (C), a C + RSG group which was treated with RSG (4 mg kg(-1)) two times a day by gavage, a diabetic group (D) that was treated with a single intraperitoneal injection of STZ (45 mg kg(-1)), D + RSG group which were treated with RSG two times a day by gavage, respectively. Lipid profiles, HbA(1c) and blood glucose levels in the circulation and malondialdehyde (MDA) and 3-nitrotyrosine (3-NT) levels in left ventricular muscle were measured. Treatment of D rats with RSG resulted in a time-dependent decrease in blood glucose. We found that the lipid profile and HbA(1c) levels in D + RSG group reached the C rat values at the end of the treatment period. There was a statistically significant difference between the C + RSG and C Groups in 3-NT levels. In group D, 3-NT and MDA levels were found to be increased when compared with C, C + RSG and D + RSG groups. In the D + RSG group, MDA levels were found to be decreased when compared with C and C + RSG. Our study suggests that the treatment of D rats with RSG for 8 weeks may decrease the oxidative/nitrosative stress in left ventricular tissue of rats. Thus in diabetes-related vascular diseases, RSG treatment may be cardioprotective. Copyright (C) 2008 John Wiley & Sons, Ltd.