Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability
Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability
复制标题
DOI：
10.1016/j.neuroimage.2005.12.040
复制
发表时间：
2006-06-01
期刊：
影响因子：
5.7
通讯作者：
Constable, R. Todd
中科院分区：
文献类型：
--
作者：
Hampson, Michelle;Tokoglu, Fuyuze;Constable, R. Todd
MRI信号的时间波动之间的相关性可以揭示个体受试者大脑区域之间的功能连接。这种相关性将是特别有用的指标功能连接，如果他们与行为表现或其他主题变量协变。这项研究调查了这种关系是否可以在大脑的阅读回路中得到证明。该方法被证明是足够强大的，以揭示显着的受试者的阅读能力之间的相关性和他们之间的功能连接的强度在阅读期间的左布罗德曼39区和布罗卡区。这表明，先前报道的阅读障碍者的角回断开是一个更大的连续体的一部分，在这个连续体中，穷人（但未受损的读者）也显示出与该区域的连接减少。此外，它说明了范式的潜在力量，检查行为和功能性大脑连接之间的相关性。(c)2006年爱思唯尔公司All rights reserved.
Correlations between temporal fluctuations in MRI signals may reveal functional connectivity between brain regions within individual subjects. Such correlations would be especially useful indices of functional connectivity if they covary with behavioral performance or other subject variables. This study investigated whether such a relationship could be demonstrated in the context of the reading circuit in the brain. The method proved sufficiently powerful to reveal significant correlations between the reading abilities of subjects and the strength of their functional connection between left Brodmann's area 39 and Broca's area during reading. This suggests that the disconnection of the angular gyrus previously reported for dyslexic readers is part of a larger continuum in which poor (but nonimpaired readers) also show reduced connectivity to the region. In addition, it illustrates the potential power of paradigms that examine correlations between behavior and functional brain connections. (c) 2006 Elsevier Inc. All rights reserved.