Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence
Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence
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DOI：
10.1016/j.oooo.2016.11.014
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发表时间：
2017-05-01
影响因子：
2.9
通讯作者：
Komori, Takahide
中科院分区：
文献类型：
--
作者：
Hasegawa, Takumi;Yanamoto, Souichi;Komori, Takahide
背景本研究旨在探讨术后同步放化疗（CRT）联合顺铂（CDDP）治疗口腔鳞癌（OSCC）的可行性，并比较术后单纯放疗（S+RT）、单纯放疗（S+RT）和放疗联合CRT（S+CRT）3组患者的预后。临床病理资料和治疗方式进行了研究。评估的终点包括局部控制（LRC）、无复发生存期、总生存期（OS）和复发类型。S+CRT组的LRC率优于仅S组（P < .001）和S+RT组（P = .044）。然而，S+RT组和S+CRT组的OS率无显著差异。在术后RT中同时使用CDDP改善了LRC。然而，在口腔鳞癌患者中，在术后放疗中同时使用CDDP对改善远处转移和OS率可能没有益处。
Background. The purpose of this study was to investigate the feasibility of postoperative concomitant chemoradiotherapy (CRT) with cisplatin (CDDP), and compare the prognosis in 3 groups-without postoperative therapy (S-only), with radiotherapy (RT) alone (S+RT), and with CRT (S+CRT) din oral squamous cell carcinoma (OSCC) patients at high risk of recurrence.Methods. Clinicopathologic data and treatment modality were investigated. Endpoints evaluated were locoregional control (LRC), relapse-free survival, overall survival (OS), and type of recurrence.Results. The S+CRT group was associated with a better LRC rate than the S-only (P < .001) and S+RT groups (P = .044). However, there was no significant difference in OS rates between the S+RT and S+CRT groups.Conclusion. The addition of concomitant CDDP to postoperative RT improved LRC. However, there may be no benefit from the addition of concomitant CDDP to postoperative RT for improvement of distant metastasis and OS rates in OSCC patients.