An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines
An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines
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DOI：
10.30683/1929-2279.2020.09.12
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
C. Krauss;Chelsey Aurelius;Kayla Johnston;Victoria H Bartlette;Sherrita Gavin;Jazmine Cuffee;Satyendra N. Banerjee;Sarah Wiseniewsky;S. Mandal;H. Banerjee
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文献类型：
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作者：
C. Krauss;Chelsey Aurelius;Kayla Johnston;Victoria H Bartlette;Sherrita Gavin;Jazmine Cuffee;Satyendra N. Banerjee;Sarah Wiseniewsky;S. Mandal;H. Banerjee
子宫内膜癌是一种恶性肿瘤，在育龄期和绝经后妇女中发病率和死亡率均呈上升趋势。铼化合物在体外细胞系和体内动物模型中都显示出对各种癌症具有治疗特性。在这项体外研究中，我们研究了一组新的铼配体对子宫癌细胞系的影响。我们的初步结果表明，这些化合物具有细胞毒性，诱导凋亡，并阻止微管蛋白聚合在这些子宫癌细胞系中，我们还发现这些新的铼化合物对健康的人血淋巴细胞是非细胞杀伤性的，从而证明了它们在未来的翻译研究中的安全性和有效性。
Endometrial cancer of the uterus is highly maslignant with an increase rate of morbidity and mortality in both childbearing age and postmenopausal women. Rhenium compounds have been shown to have therapeutic properties against various cancers both in vitro cell lines and in vivo animal models. In this in vitro study, we investigated the effects of a novel group of Rhenium ligands on a uterine cancer cell line. Our initial results showed that these compounds are cytotoxic, induces apoptosis and prevents tubulin polymerization in these uterine cancer cell lines, we also found these novel Rhenium compounds to be noncytocidal to healthy human blood lymphocyte cells, thus proving their safety and efficacy in future translational studies.