Baseline cortical excitability determines whether TMS disrupts or facilitates behavior
Baseline cortical excitability determines whether TMS disrupts or facilitates behavior
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DOI：
10.1152/jn.01392.2007
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Pascual-Leone, Alvaro
中科院分区：
文献类型：
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作者：
Silvanto, Juha;Cattaneo, Zaira;Pascual-Leone, Alvaro
经颅磁刺激（TMS）越来越多地用于非侵入性地改变大脑活动和研究大脑行为关系。然而，结果可能是可变的，影响TMS功能疗效的条件仍不清楚。在这里，我们表明，在线TMS可以促进或抑制知觉功能，这取决于目标大脑区域的活动的基线水平。在简单的运动检测任务中，当TMS应用于运动选择区域V5/MT时，受试者的运动检测能力受损。类似地，使用离线1 Hz重复TMS（rTMS）抑制V5/MT活动会破坏后续运动检测任务的性能。然而，矛盾的是，在线V5/MT TMS有一个促进作用的运动检测，如果V5/MT已被抑制离线1赫兹rTMS之前的运动检测任务。这些结果表明，当目标神经群体处于抑制状态时，TMS可以对行为产生意想不到的促进作用。我们的研究结果提供了进一步的证据，认为TMS的影响是由目标神经群体的初始激活状态调制。
Transcranial magnetic stimulation (TMS) is increasingly used to modify brain activity noninvasively and to study brain-behavior relations. However, results can be variable and the conditions that affect the functional efficacy of TMS remain unclear. Here we show that on-line TMS can either facilitate or suppress perceptual functions depending on the baseline level of activity of the targeted brain region. When TMS was applied over the motion selective region V5/MT during a simple motion-detection task, subjects' motion-detection ability was impaired. Similarly, suppression of V5/MT activity using off-line 1 Hz repetitive TMS (rTMS) disrupted performance in a subsequent motion-detection task. However, paradoxically, on-line V5/MT TMS had a facilitatory effect on motion detection if V5/MT had been suppressed by off-line 1-Hz rTMS prior to the motion-detection task. These results demonstrate that TMS can have an unexpected facilitatory effect on behavior when the targeted neural population is in a suppressed state. Our findings provide further evidence for the view that the effects of TMS are modulated by the initial activation state of the targeted neural population.