A green cyclodextrin metal-organic framework as solid-phase extraction medium for enrichment of sulfonamides before their HPLC determination
A green cyclodextrin metal-organic framework as solid-phase extraction medium for enrichment of sulfonamides before their HPLC determination
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绿色环糊精金属有机框架作为固相萃取介质，用于在 HPLC 测定前富集磺酰胺类药物
DOI：
10.1016/j.microc.2018.01.038
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发表时间：
2018-05-01
影响因子：
4.8
通讯作者：
Li, Qiang
中科院分区：
文献类型：
--
作者：
Li, Yuanyuan;Zhu, Nan;Li, Qiang
以γ-环糊精（gamma-CD）和碱金属阳离子为原料，采用一种简便的方法制备了环糊精金属有机骨架（CD-MOF）。作为一种绿色、可再生的骨架材料，CD-MOF对磺胺类药物具有很高的选择性和吸附能力。为此，以磺胺嘧啶（STZ）、磺胺甲氧嘧啶（SMD）、磺胺甲基嘧啶（SMR）、磺胺二甲氧嘧啶（SDM）和磺胺喹喔啉（SQX）等5种磺胺类药物为目标物，结合高效液相色谱（HPLC），对CD-MOF作为固相萃取（SPE）吸附剂的萃取性能进行了验证，并对其吸附机理进行了研究。结果表明，CD-MOF对5种水杨酸具有较好的富集能力，吸附平衡时间较短（30 min）。在优化的条件下，加标回收率为76%~ 102%，相对标准偏差小于2.4%~ 6.5%（n = 3），适用于复杂基质中水杨酸的有效提取。(C)2018由Elsevier B. V.出版
A facile approach was used to prepare a cyclodextrin metal-organic framework(CD-MOF) based on gamma-cydodextrins (gamma-CDs) and alkali metal cations. As a green, renewable framework material, the CD-MOF exhibits high selectivity and sorptive capacity toward sulfonamides (SAs). Therefore, five SAs including sulfathiazloe(STZ), sulfamethoxymidine(SMD), sulfamerazine(SMR), sulfadimethoxine (SDM)and sulfaquinoxaline (SQX) were selected as target analytes to validate the extraction performance of CD-MOF as a solid-phase extraction (SPE) adsorbent, coupled with high-performance liquid chromatography (HPLC) and the adsorption mechanism was investigated. The results showed that the CD-MOF as adsorbent exhibited good enrichment capability for five SAs and obtained short adsorption equilibrium time(30 min). Under optimized conditions, the spiked recoveries into meat samples were satisfied (76%-102%) with relative standard deviation below 2.4%-6.5% (n = 3) which indicated that the method was suitable for the effective extraction of SAs from complicated matrices. (C) 2018 Published by Elsevier B.V.