Association between prepregnancy maternal body mass index and the risk of having an infant with a congenital diaphragmatic hernia.
Association between prepregnancy maternal body mass index and the risk of having an infant with a congenital diaphragmatic hernia.
复制标题
孕前母亲体重指数与婴儿患有先天性膈疝的风险之间的关联。
DOI：
10.1002/bdra.10003
复制
发表时间：
2003
期刊：
影响因子：
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通讯作者：
Mitchell,AllenA
中科院分区：
文献类型：
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作者：
Waller,DKim;Tita,AlanTN;Werler,MarthaM;Mitchell,AllenA
BACKGROUNDA previous study observed that women who are underweight prior to conception were significantly more likely to have infants affected by congenital diaphragmatic hernia (CDH). The objective of the current study was to examine the association between maternal body mass index and the risk of a CDH‐affected offspring based on a larger number of cases of CDH.METHODSA case control study was conducted using data collected by the Boston University Slone Epidemiology Center Birth Defects Study, which identifies infants with major malformations who are born in the metropolitan area surrounding Boston, Massachusetts; Philadelphia, Pennsylvania; and Toronto, Ontario, Canada. Control infants were selected from infants without malformations who were born in the same areas. The study included 85 cases of CDH and 655 controls delivered between 1993 and 1997.RESULTSAfter adjustment for maternal education and maternal age, we observed that women who were thin or underweight for their height (body mass index ≤ 19.0 kg/m2) had an increased risk of having an infant with isolated CDH (OR = 1.9; 95% CI = 0.92–4.1), but no increase in the risk of having a CDH infant with multiple defects (OR = 0.86; 95% CI = 0.29–2.6) compared with all other women.CONCLUSIONSAlthough our finding for isolated CDH was not statistically significant (P= 0.08), it suggests that the offspring of thin or underweight women may have an increased risk of isolated CDH. This finding requires confirmation. If it is confirmed, further research on factors associated with being underweight should be explored such as diet, exercise, and use of drugs. Birth Defects Research (Part A) 67:73–76, 2003. © 2003 Wiley‐Liss, Inc.
用于研究人体污染物气体和气溶胶的暴露室：设计考虑因素
DOI：
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发表时间：
1984
期刊：
影响因子：
--
作者：
M. Utell;P. Morrow;R. Hyde;R. Schreck
通讯作者：
R. Schreck
影响因子：
8.3
作者：
FRAMPTON, MW;SMEGLIN, AM;UTELL, MJ
通讯作者：
UTELL, MJ
正常和轻度哮喘受试者的气道对硝酸盐的反应性。
DOI：
10.1152/jappl.1979.46.1.189
发表时间：
1979
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
M. Utell;A. J. Swinburne;R. Hyde;D. M. Speers;F. Gibb;P. Morrow
通讯作者：
P. Morrow