Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits.
Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits.
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DOI：
10.1093/cercor/bhm030
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
H. Yamasue;O. Abe;M. Suga;Haruyasu Yamada;H. Inoue;Mamoru Tochigi;M. Rogers;S. Aoki;N. Kato;K. Kasai
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文献类型：
--
作者：
H. Yamasue;O. Abe;M. Suga;Haruyasu Yamada;H. Inoue;Mamoru Tochigi;M. Rogers;S. Aoki;N. Kato;K. Kasai
探索区域脑容量和焦虑相关的人格特质之间的关系对于理解先前存在的抑郁和焦虑障碍的脆弱性是很重要的。然而，以前关于这个主题的研究采用了相对有限的样本量和/或图像处理方法，他们没有澄清可能的性别差异。在本研究中，183（男/女：117/66）右利手的健康人在第三和第四个十年的生活进行了结构磁共振成像扫描和气质和性格清单。神经解剖学的个体差异的伤害回避（HA）的分数进行了检查，在整个大脑中使用基于体素的形态测量。我们发现，HA评分越高，右侧海马体的区域灰质体积越小，这在两种性别中都很常见。与此相反，女性特定的相关性被发现之间的较高的焦虑相关的人格特质和较小的区域大脑体积在左前额叶皮层。目前的研究结果表明，较小的右海马体积的基础上，更高的焦虑相关的特质共同的性别，而前额叶体积只在女性。这些结果可能会对为什么对焦虑症和抑郁症等压力相关疾病的易感性显示出性别和/或个体差异产生影响。
Exploration of the relationships between regional brain volume and anxiety-related personality traits is important for understanding preexisting vulnerability to depressive and anxiety disorders. However, previous studies on this topic have employed relatively limited sample sizes and/or image processing methodology, and they have not clarified possible gender differences. In the present study, 183 (male/female: 117/66) right-handed healthy individuals in the third and fourth decades of life underwent structural magnetic resonance imaging scans and Temperament and Character Inventory. Neuroanatomical correlates of individual differences in the score of harm avoidance (HA) were examined throughout the entire brain using voxel-based morphometry. We found that higher scores on HA were associated with smaller regional gray matter volume in the right hippocampus, which was common to both genders. In contrast, female-specific correlation was found between higher anxiety-related personality traits and smaller regional brain volume in the left anterior prefrontal cortex. The present findings suggest that smaller right hippocampal volume underlies the basis for higher anxiety-related traits common to both genders, whereas anterior prefrontal volume contributes only in females. The results may have implications for why susceptibility to stress-related disorders such as anxiety disorders and depression shows gender and/or individual differences.