Nasal carriage of Staphylococcus aureus and methicillin-resistant S aureus in the United States, 2001-2002
Nasal carriage of Staphylococcus aureus and methicillin-resistant S aureus in the United States, 2001-2002
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DOI：
10.1370/afm.526
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发表时间：
2006-03-01
影响因子：
4.4
通讯作者：
Diaz, VA
中科院分区：
文献类型：
--
作者：
Mainous, AG;Hueston, WJ;Diaz, VA
金黄色葡萄球菌是侵袭性感染的常见原因，但大多数流行率评估是基于卫生保健样本。我们计算了基于人群的鼻腔携带金黄色葡萄球菌的估计值和携带的风险因素，方法我们使用2001-2002年国家健康和营养调查（NHANES）来估计非吸烟人群中金黄色葡萄球菌和MRSA的携带情况。结果估计有8690万人（占总人口的32.40%）被金黄色葡萄球菌定殖。金黄色葡萄球菌分离株中MRSA的患病率为2.58%，估计MRSA的人群携带率为0.84%或220万人。在金黄色葡萄球菌分离株的个体中，65岁或以上的个体MRSA患病率最高（8.28%）。在所有的种族/民族群体的研究，西班牙裔有最高的流行率与金黄色葡萄球菌的殖民化，但殖民化时，不太可能有MRSA.CONCLUSIONS这第一次全国代表性的评估携带金黄色葡萄球菌表明，近三分之一的人口目前由这种生物体殖民化。虽然MRSA的流行率仍然很低，但超过220万人携带这种耐药微生物;因此，在促进适当的微生物传播方案方面保持警惕仍然是一个优先事项。
PURPOSE Staphylococcus aureus is a common cause of invasive infections, yet most assessments of prevalence are based on health care-based samples. We computed population-based estimates of nasal carriage of S aureus and risk factors for carriage, as well as population-based estimates of nasal carriage of methicillin-resistant S aureus (MRSA).METHODS We used the National Health and Nutrition Examination Survey (NHANES) 2001-2002 to estimate carriage of S aureus and MRSA for the non-institutionalized US population including children and adults.RESULTS An estimated 86.9 million persons (32.40% of the population) were colonized with S aureus. The prevalence of MRSA among S aureus isolates was 2.58%, for an estimated population carriage of MRSA of 0.84% or 2.2 million persons. Among individuals with S aureus isolates, individuals aged 65 years or older had the highest MRSA prevalence (8.28%). Among all the racial/ethnic groups studied, Hispanics had the highest prevalence of colonization with S aureus but, when colonized, were less likely to have MRSA.CONCLUSIONS This first nationally representative assessment of carriage of S aureus indicates that nearly one third of the population is currently colonized by this organism. Although the prevalence of MRSA remains low, more than 2.2 million people carry this resistant organism; thus, vigilance in promoting appropriate microbial transmission protocols should remain a priority.