Strong and macroporous calcium phosphate cement: Effects of porosity and fiber reinforcement on mechanical properties
Strong and macroporous calcium phosphate cement: Effects of porosity and fiber reinforcement on mechanical properties
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DOI：
10.1002/1097-4636(20011205)57:3
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发表时间：
2001-12-05
期刊：
影响因子：
--
通讯作者：
Eichmiller, FC
中科院分区：
文献类型：
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作者：
Xu, HHK;Quinn, JB;Eichmiller, FC
自固化磷酸钙骨水泥（CPC）具有良好的骨传导性和骨替代能力，已被广泛应用于临床。为了更快的吸收和伴随的骨整合，希望在CPC中建立大孔的方法;然而，这降低了其机械性能。因此，本研究的目的是使用纤维来增强大孔CPC，并研究孔体积分数对其力学性能的影响。将水溶性甘露醇晶体掺入CPC糊剂中;然后将凝固的CPC浸入水中以溶解甘露醇，产生大孔。使用0、10、20、30和40%的甘露醇/（甘露醇+ CPC粉末）质量分数。将体积分数为6%的芳族聚酰胺纤维掺入CPC-甘露醇中。将样品置于3 mm × 4 mm × 25 mm的模具中，然后在三点弯曲中断裂，以测量强度、断裂功和模量。甘露醇的溶解产生了良好形成的大孔，其中40%甘露醇的CPC具有70.8%体积分数的总孔隙率。增加甘露醇含量显著降低了无纤维CPC的性能（方差分析; p < 0.001）。0%甘露醇时CPC的强度（平均标准差; n = 6）为15.0 +/- 1.8 MPa; 40%甘露醇时，其降低至1.4 +/- 0.4 MPa。纤维增强改善了性能，在0%甘露醇下强度增加了3倍，在30%甘露醇下增加了7倍，在40%甘露醇下增加了近4倍。纤维增强使复合材料的断裂功提高了2个数量级，但模量没有发生变化。对试样的扫描电子显微镜检查表明，裂纹偏转和纤维桥接、基体多重开裂和纤维摩擦拔出是增强机制。通过纤维增强，大孔CPC得到显著增强和增韧。这可能有助于将具有大孔的CPC用于骨长入，以修复应力承受部位的较大缺损。(C)John Wiley & Sons，Inc.
Because of its excellent osteoconductivity and bone-replacement capability, self-setting calcium phosphate cement (CPC) has been used in a number of clinical procedures. For more rapid resorption and concomitant osseointegration, methods were desired to build macropores into CPC; however, this decreased its mechanical properties. The aims of this study, therefore, were to use fibers to strengthen macroporous CPC and to investigate the effects of the pore volume fraction on its mechanical properties. Water-soluble mannitol crystals were incorporated into CPC paste; the set CPC was then immersed in water to dissolve mannitol, producing macropores. Mannitol/(mannitol + CPC powder) mass fractions of 0, 10, 20, 30, and 40% were used. An aramid fiber volume fraction of 6% was incorporated into the CPC-mannitol. specimens, which were set in 3 mm x 4 mm x 25 mm. molds and then fractured in three-point flexure to measure the strength, work of fracture, and modulus. The dissolution of mannitol created well-formed macropores, with CPC at 40% mannitol having a total porosity of a 70.8% volume fraction. Increasing the mannitol content significantly decreased the properties of CPC without fibers (analysis of variance; p < 0.001). The strength (mean standard deviation; n = 6) of CPC at 0% mannitol was 15.0 +/- 1.8 MPa; at 40% mannitol, it decreased to 1.4 +/- 0.4 MPa. Fiber reinforcement improved the properties, with the strength increasing threefold at 0% mannitol, sevenfold at 30% mannitol, and nearly fourfold at 40% mannitol. The work of fracture increased by 2 orders of magnitude, but the modulus was not changed as a result of fiber reinforcement. A scanning electron microscopy examination of specimens indicated crack deflection and bridging by fibers, matrix multiple cracking, and frictional pullout of fibers as the reinforcement mechanisms. Macroporous CPCs were substantially strengthened and toughened via fiber reinforcement. This may help extend the use of CPCs with macropores for bony ingrowth to the repair of larger defects in stress-bearing locations. (C) 2001 John Wiley & Sons, Inc.