Noncanonical Hedgehog signaling.
Noncanonical Hedgehog signaling.
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DOI：
10.1016/b978-0-12-394622-5.00003-1
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发表时间：
2012
影响因子：
--
通讯作者：
Riobo, Natalia A.
中科院分区：
文献类型：
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作者：
Brennan, Donna;Chen, Xiaole;Cheng, Lan;Mahoney, My;Riobo, Natalia A.
哺乳动物中的非经典刺猬（Hh）信号的概念已经开始得到许多观察的支持。通过非经典，我们指的是所有这些细胞和组织的反应，任何Hh亚型是独立的转录变化介导的Gli家族的转录因子。在这一章中，我们讨论了最新的研究结果表明，Patched1可以调节细胞增殖和凋亡独立的Smoothened（Smo）和Gli和报告，Smo调制肌动蛋白依赖的过程，如成纤维细胞迁移，内皮细胞tubulogenesis，轴突延伸，神经突形成的不同机制，排除任何参与Gli依赖的转录。我们也承认在果蝇中存在不太强的非经典信号的证据。
The notion of noncanonical hedgehog (Hh) signaling in mammals has started to receive support from numerous observations. By noncanonical, we refer to all those cellular and tissue responses to any of the Hh isoforms that are independent of transcriptional changes mediated by the Gli family of transcription factors. In this chapter, we discuss the most recent findings that suggest that Patched1 can regulate cell proliferation and apoptosis independently of Smoothened (Smo) and Gli and the reports that Smo modulates actin cytoskeleton-dependent processes such as fibroblast migration, endothelial cell tubulogenesis, axonal extension, and neurite formation by diverse mechanisms that exclude any involvement of Gli-dependent transcription. We also acknowledge the existence of less stronger evidence of noncanonical signaling in Drosophila.