Boiogito prevents dietary lithocholic acid (LCA)‐induced cholestatic liver injury through the suppression of intestinal LCA absorption

Boiogito prevents dietary lithocholic acid (LCA)‐induced cholestatic liver injury through the suppression of intestinal LCA absorption
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DOI：
10.1002/tkm2.1214
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发表时间：
2019-08
期刊：
Traditional & Kampo Medicine
影响因子：
--
通讯作者：
Shiro Watanabe;Zhuoer Chen;Kyosuke Fujita
Shiro Watanabe;Zhuoer Chen;Kyosuke Fujita
中科院分区：
其他
文献类型：
--
作者：
Shiro Watanabe;Zhuoer Chen;Kyosuke Fujita

文献摘要

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在小鼠中检查boiogito（BOT）对由饮食和腹腔内石胆酸（LCA）处理诱导的肝损伤和肝胆汁酸变化的影响。此外，我们还研究了口服LCA后，BOT是否会改变盲肠和粪便中LCA的水平。
The effects of boiogito (BOT) on liver injury and on the changes in hepatic bile acid induced by dietary and i.p. lithocholic acid (LCA) treatment were examined in mice. Furthermore, we examined whether BOT alters the level of LCA in the cecum and feces after oral LCA loading.