Septum formation, cell division, and sporulation in mutants of yeast deficient in proteinase B.
Septum formation, cell division, and sporulation in mutants of yeast deficient in proteinase B.
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缺乏蛋白酶 B 的酵母突变体中的隔膜形成、细胞分裂和孢子形成。
DOI：
10.1073/pnas.76.5.2395
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发表时间：
1979
影响因子：
11.1
通讯作者：
E. W. Jones
中科院分区：
文献类型：
--
作者：
G. Zubenko;A. Mitchell;E. W. Jones
携带蛋白酶 B 结构基因 prb1 损伤的酿酒酵母突变体已被分离出来。蛋白酶 B 被认为参与几丁质合酶酶原的激活，以允许在出芽过程中形成隔膜并参与孢子形成。 prb1 突变体能够生长和分裂，并且它们形成明显正常的含有几丁质的隔膜。大多数 prb1 突变纯合的二倍体无法完成孢子形成。
Mutants of Saccharomyces cerevisiae that carry lesions in the structural gene for proteinase B, prb1, have been isolated. Proteinase B was thought to be involved in activation of chitin synthase zymogen to allow septum formation during budding and to be involved in sporulation. The prb1 mutants are able to grow and divide and they form apparently normal septa that contain chitin. Most diploids homozygous for prb1 mutations are unable to complete sporulation.