Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons.
Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons.
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DOI：
10.1155/2015/135787
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发表时间：
2015
影响因子：
--
通讯作者：
Kitajima T
中科院分区：
文献类型：
--
作者：
Vazifehkhah Ghaffari B;Kouhnavard M;Aihara T;Kitajima T
各种类型的神经元对波动的正弦输入电流表现出阈下共振振荡（优选频率响应）。这种现象影响了突触可塑性和神经网络振荡的频率。本研究通过数学建模评估了中枢模式发生器网络中起搏幽门扩张器（PD）神经元的共振特性。从药理学的角度来看，不去除钙依赖性钾电流，PD神经元中的钙电流就不能被阻断。因此，钙（ICa）和钙依赖性钾（IKCa）电流对共振特性的影响仍不清楚。利用Hodgkin-Huxley型神经元模型及其等效RLC电路，我们研究了静息膜电位和离子电流变化对共振的影响。结果表明，改变静息膜电位的影响共振的振幅和频率，使共振的强度（Q值）增加的静息膜电位的去极化和超极化。此外，超极化激活的内向电流（Ih）和ICa（与IKCa相关）分别是超极化和去极化电位下共振特性的主导因素。通过数学分析，结果表明，Ih和IKCa影响PD神经元的谐振特性。然而，ICa仅对这些神经元的共振振幅具有放大作用。
Various types of neurons exhibit subthreshold resonance oscillation (preferred frequency response) to fluctuating sinusoidal input currents. This phenomenon is well known to influence the synaptic plasticity and frequency of neural network oscillation. This study evaluates the resonant properties of pacemaker pyloric dilator (PD) neurons in the central pattern generator network through mathematical modeling. From the pharmacological point of view, calcium currents cannot be blocked in PD neurons without removing the calcium-dependent potassium current. Thus, the effects of calcium (I Ca) and calcium-dependent potassium (I KCa) currents on resonant properties remain unclear. By taking advantage of Hodgkin-Huxley-type model of neuron and its equivalent RLC circuit, we examine the effects of changing resting membrane potential and those ionic currents on the resonance. Results show that changing the resting membrane potential influences the amplitude and frequency of resonance so that the strength of resonance (Q-value) increases by both depolarization and hyperpolarization of the resting membrane potential. Moreover, hyperpolarization-activated inward current (I h) and I Ca (in association with I KCa) are dominant factors on resonant properties at hyperpolarized and depolarized potentials, respectively. Through mathematical analysis, results indicate that I h and I KCa affect the resonant properties of PD neurons. However, I Ca only has an amplifying effect on the resonance amplitude of these neurons.
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DOI：
10.1523/jneurosci.1654-11.2011
发表时间：
2011-08-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Yoshida M;Giocomo LM;Boardman I;Hasselmo ME
通讯作者：
Hasselmo ME
影响因子：
5.5
作者：
GUTFREUND, Y;YAROM, Y;SEGEV, I
通讯作者：
SEGEV, I
影响因子：
3.3
作者：
Lampl, I;Yarom, Y
通讯作者：
Yarom, Y
影响因子：
5.5
作者：
Erchova, I;Kreck, G;Herz, AVM
通讯作者：
Herz, AVM
影响因子：
2.5
作者：
Soto-Treviño, C;Rabbah, P;Nadim, F
通讯作者：
Nadim, F