Integrins and human intestinal cell functions
Integrins and human intestinal cell functions
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DOI：
10.2741/beaulieu
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发表时间：
1999-03-15
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影响因子：
--
通讯作者：
Beaulieu, Jean-Francois
中科院分区：
文献类型：
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作者：
Beaulieu, Jean-Francois
整合素是一个细胞表面受体大家族，参与细胞与细胞外基质的黏附。在上皮细胞中，主要是属于β1和β4类的整合素与基底膜分子如层粘连蛋白和IV型胶原结合。Beta1和Beta4整合素调节粘连连接的组装，以及各种信号通路的激活，导致基因表达的调节。在这篇综述中，我将讨论目前已知的关于人类肠道上皮细胞整合素的情况。对肠道细胞模型分析细胞-基质相互作用的兴趣将被勾勒出来，最近的实验证据表明这些相互作用可以调节细胞的增殖和分化。
Integrins are a large family of cell-surface receptors involved in cell adhesion to the extracellular matrix. In epithelia, it is mainly the integrins belonging to the beta1 and beta4 classes that bind to basement membrane molecules such as the laminins and the type IV collagens. Beta1 and beta4 integrins regulate the assembly of adhesive junctions as well as the activation of various signaling pathways leading to the modulation of gene expression. In this review, I will discuss what is currently known about integrins in human intestinal epithelial cells. The interest in the intestinal cell model to analyze cell-matrix interactions will be delineated and the recent experimental evidence showing that these interactions can regulate cell proliferation and differentiation will be presented.