QUANTITATIVE MICRODIALYSIS OF NEUROTRANSMITTERS
QUANTITATIVE MICRODIALYSIS OF NEUROTRANSMITTERS
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DOI：
10.1016/0165-0270(93)90097-b
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发表时间：
1993-07-01
影响因子：
3
通讯作者：
JUSTICE, JB
中科院分区：
文献类型：
--
作者：
JUSTICE, JB
描述了在基础和瞬时条件下用于定量测定神经递质胞外浓度的微透析法。以测量大鼠伏隔核和纹状体中的多巴胺(DA)为例。综述了影响神经递质微透析回收率的因素。用计算机模拟考察了释放和摄取对微透析恢复的影响。提出了微渗析的几种新应用。
Microdialysis methods for the quantitative determination of the extracellular concentration of neurotransmitters are described for basal and transient conditions. Measurements of dopamine (DA) in the nucleus accumbens and striatum of the rat are used as examples. The factors affecting microdialysis recovery of neurotransmitters are reviewed. Computer simulation is used to examine the effect of release and uptake on microdialysis recovery. Several new applications of microdialysis are suggested.