POTENTIATION OF DEVELOPING NEUROMUSCULAR SYNAPSES BY THE NEUROTROPHINS NT-3 AND BDNF
POTENTIATION OF DEVELOPING NEUROMUSCULAR SYNAPSES BY THE NEUROTROPHINS NT-3 AND BDNF
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DOI：
10.1038/363350a0
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发表时间：
1993-05-27
期刊：
影响因子：
64.8
通讯作者：
POO, MM
中科院分区：
文献类型：
--
作者：
LOHOF, AM;IP, NY;POO, MM
神经营养因子是促进各种神经元群体存活和分化的神经营养因子家族1,2。尽管神经营养蛋白对神经元存活和分化的长期影响已被深入研究，但对其对突触功能的影响却一无所知。在这里，我们报告急性暴露于神经营养蛋白-3 (NT-3)3,4 或脑源性神经营养因子 (BDNF)5，但不是神经生长因子 (NGF)6，会迅速增强培养物中正在发育的神经肌肉突触的自发和冲动诱发的突触活动。该效应似乎起源于突触前，并由受体酪氨酸激酶 Trk 家族介导。这些结果为神经营养素调节突触发育的功能提供了证据。
THE neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations1,2. Although the long-term effects of neurotrophins on neuronal survival and differentiation have been intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure to neurotrophin-3 (NT-3)3,4 or brain-derived neurotrophic factor (BDNF)5, but not nerve growth factor (NGF)6, rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin and to be mediated by the Trk family of receptor tyrosine kinases7. These results provide evidence for the regulation of the function of developing synapses by neurotrophins.