Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis
Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis
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DOI：
10.1016/j.clnu.2010.01.008
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发表时间：
2010-08-01
影响因子：
6.3
通讯作者：
Lee, Jae Ho
中科院分区：
文献类型：
--
作者：
Kim, Ji Hae;Lee, Choon-Taek;Lee, Jae Ho
背景与目的：营养不良是结核病的一个显著特征。关于食欲相关激素，饥饿素和瘦素在结核病营养不良中的作用知之甚少。本研究旨在探讨ghrelin和leptin对活动性肺结核患者营养不良的影响。方法：前瞻性检测23例肺结核患者和23例健康对照者治疗前和化疗后临床症状改善后的营养参数和血浆ghrelin、leptin及炎性细胞因子水平。结果：营养不良组的Ghrelin水平显著低于营养良好组[44.0（43.0-54.0）vs.122（108-158）pg/mL; p < 0.05]，而瘦素水平无显著差异。营养不良评分与ghrelin呈负相关（p = 0.76，p < 0.01），但与瘦素水平无相关性。营养不良的结核病组的TNF-α和IL-6水平显著高于营养良好的结核病组和对照组。血浆生长素释放肽的水平往往会减少，炎症细胞因子增加treatment.Conclusions：血浆生长素释放肽水平下降，除了增加血浆炎症细胞因子水平，可能与活动性肺结核营养不良。(C)2010年爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Backgrounds & aims: Malnutrition is a prominent feature of tuberculosis. Little is known about the role of the appetite-related hormones, ghrelin and leptin, in malnutrition in tuberculosis. This study was undertaken to determine whether ghrelin and leptin contribute to malnutrition in active pulmonary tuberculosis.Methods: Nutritional parameters and plasma levels of ghrelin, leptin, and inflammatory cytokines were measured before treatment and after clinical improvement following anti-tuberculosis chemotherapy in 23 tuberculosis subjects and 23 healthy controls prospectively. Patients were divided into well-nourished (n = 15) and malnourished (n = 8) groups.Results: Ghrelin but not leptin levels were significantly lower in the malnourished tuberculosis group than in the well-nourished tuberculosis group [44.0 (43.0-54.0) vs. 122 (108-158) pg/mL; p < 0.05]. Malnutrition score was negatively correlated to ghrelin (p = 0.76, p < 0.01) but not to leptin levels. TNF-alpha and IL-6 levels were significantly higher in the malnourished tuberculosis group than in the well-nourished tuberculosis group and controls. Plasma levels of ghrelin tended to decrease as inflammatory cytokines increased before treatment.Conclusions: Decreased plasma ghrelin levels, in addition to increased plasma inflammatory cytokine levels, may be associated with malnutrition in active pulmonary tuberculosis. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.