Seroprevalence of anti-H5 antibody in rural Cambodia, 2007
Seroprevalence of anti-H5 antibody in rural Cambodia, 2007
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DOI：
10.1016/j.jcv.2010.02.021
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发表时间：
2010-06-01
影响因子：
8.8
通讯作者：
Buchy, Philippe
中科院分区：
文献类型：
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作者：
Cavailler, Philippe;Chu, Simon;Buchy, Philippe
背景：自2005年以来，柬埔寨已实验室确诊8例H5N1感染患者。尽管高致病性禽流感H5N1病毒广泛传播，且家禽的暴露程度很高，但越来越多的证据表明H5N1病毒可能不容易传播给人类。目的：评估 H5N1 在柬埔寨农村地区的传播频率，确定人类中 H5N1 的潜在危险因素，并探讨人类中无症状和临床轻度疾病的程度。研究设计：2007 年 4 月，在确认 H5N1 感染导致一名 13 岁女性死亡后 9 周，进行了一项血清流行病学调查。从 700 名参与者中采集了血液样本进行 H5N1 血清学检测。所有参与者均接受标准化问卷调查，收集家禽暴露信息。结果：700 名村民中有 18 名（2.6%）H5N1 抗体检测呈阳性。这 18 个人比血清阴性参与者更有可能报告在社区池塘洗澡或游泳 (p = 0.04)。结论：H5N1 抗体的血清阳性率高于之前在柬埔寨和泰国进行的其他调查中报告的。这一发现强化了压倒性的证据，表明该病毒继续在人类高度接触家禽的环境中广泛传播。我们的研究结果提供了额外的证据，表明在社区池塘洗澡或游泳仍然是 H5N1 感染的重要潜在危险因素。野生鸟类和家禽都可以自由进入这些池塘，这些池塘还通过倾倒家禽粪便来喂养鱼类，用于水产养殖。 (C) 2010 Elsevier B.V. 保留所有权利。
Background: Since 2005, eight patients with H5N1 infection were laboratory confirmed in Cambodia. Despite the widespread of highly pathogenic avian influenza H5N1 virus and the intense exposure to poultry, there is growing evidence that H5N1 viruses may not be easily transmitted to human. Objectives: To evaluate the frequency of H5N1 transmission in rural Cambodia, to identify potential risk factors for H5N1 in humans and to explore the extent of asymptomatic and clinically mild illness among humans.Study design: A seroepidemiologic survey was conducted, 9 weeks after the recognition that H5N1 infection caused the death of a 13 years old female in April 2007. Blood specimens were collected from 700 participants for H5N1 serological testing. All participants were interviewed with standardized questionnaire to collect information about poultry exposure.Results: Eighteen (2.6%) of the 700 villagers were tested positive cases for H5N1 antibodies. These 18 individuals were more likely than seronegative participants to report bathing or swimming in the community pond (p = 0.04).Conclusions: The seroprevalence of H5N1 antibodies was higher than previously reported in the other investigations conducted in Cambodia and Thailand. This finding reinforces the overwhelming evidence that the virus continues to circulate widely in settings where human have high exposure to poultry. Our results, provides additional evidence suggesting that bathing or swimming in the community ponds, remains important potential risk factor for H5N1 infection. Both wild birds and domestic poultry have free access to these ponds which are also used for aquaculture through the dumping of poultry feces for fish feeding. (C) 2010 Elsevier B.V. All rights reserved.