Delayed ventilation assessment using fast dynamic hyperpolarised Xenon-129 magnetic resonance imaging
Delayed ventilation assessment using fast dynamic hyperpolarised Xenon-129 magnetic resonance imaging
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DOI：
10.1007/s00330-019-06415-1
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发表时间：
2020-02-01
影响因子：
5.9
通讯作者：
Gleeson, Fergus
中科院分区：
文献类型：
--
作者：
Chen, Mitchell;Doganay, Ozkan;Gleeson, Fergus
目的 研究使用快速动态超极化 Xe-129 通气磁共振成像 (DXeV-MRI) 方法检测和量化慢性阻塞性肺疾病 (COPD) 患者的通气延迟。方法 3 名肺部健康的男性参与者（年龄范围 31-43 岁）和 15 名患有 COPD（II-IV 期）的患者（M/F = 12:3，年龄范围 = 48-73）接受了肺活量测定测试、定量胸部计算机断层扫描 (QCT) 和 1.5 特斯拉的 DXeV-MRI。通过测量每个感兴趣的肺部区域 (ROI) 与气管中的时间信号变化相比，捕获区域延迟通气。除了临床放射科医生通过目视检查进行定性评估外，还通过计算肺 ROI 和气管信号的协方差测量来定量捕获延迟通气，并使用时间延迟和两个信号的信号时间曲线覆盖的积分面积之间的差异进行量化。结果所有患者的 DXeV-MRI 都证明了区域颞通气与自由呼吸周期中预期的生理变化一致。 15 名 COPD 患者中，有 13 名观察到通气延迟，并且涉及可变的肺部 ROI。这与对照组形成鲜明对比，对照组没有出现通气延迟 (p = 0.0173)。结论 DXeV-MRI 提供了一种无创检测和量化 COPD 患者通气延迟的方法，并提供整个呼吸周期期间局部肺功能的生理信息。
Objectives To investigate the use of a fast dynamic hyperpolarised Xe-129 ventilation magnetic resonance imaging (DXeV-MRI) method for detecting and quantifying delayed ventilation in patients with chronic obstructive pulmonary disease (COPD). Methods Three male participants (age range 31-43) with healthy lungs and 15 patients (M/F = 12:3, age range = 48-73) with COPD (stages II-IV) underwent spirometry tests, quantitative chest computed tomography (QCT), and DXeV-MRI at 1.5-Tesla. Regional delayed ventilation was captured by measuring the temporal signal change in each lung region of interest (ROI) in comparison to that in the trachea. In addition to its qualitative assessment through visual inspection by a clinical radiologist, delayed ventilation was quantitatively captured by calculating a covariance measurement of the lung ROI and trachea signals, and quantified using both the time delay, and the difference between the integrated areas covered by the signal-time curves of the two signals. Results Regional temporal ventilation, consistent with the expected physiological changes across a free breathing cycle, was demonstrated with DXeV-MRI in all patients. Delayed ventilation was observed in 13 of the 15 COPD patients and involved variable lung ROIs. This was in contrast to the control group, where no delayed ventilation was demonstrated (p = 0.0173). Conclusions DXeV-MRI offers a non-invasive way of detecting and quantifying delayed ventilation in patients with COPD, and provides physiological information on regional pulmonary function during a full breathing cycle.